tirabrutinib hydrochloride
Tirabrutinib is a potent and selective Bruton’s tyrosine kinase (BTK) inhibitor that irreversibly and covalently binds to BTK Cys-481 in B cells and inhibits aberrant B cell receptor signalling in B cell-related cancers and autoimmune diseases.
Ligand Summary
UNII: LXG44NDL2T
PubChem: 54755438
ChEMBL: CHEMBL4071161
DrugCentral: 5423
LyCHI: S9QKYJ1XVN7L
Target Activities
BTK
Tyrosine-protein kinase BTK
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.28 | J Med Chem, (2020) 63:10:5102 | ||||
Kd | 7.85 | J Med Chem, (2020) 63:10:5102 | ||||
IC50 | 7.58 | J Med Chem, (2020) 63:10:5102 | ||||
IC50 | 8.17 | INHIBITOR | ||||
TEC
Tyrosine-protein kinase Tec
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 8.21 | J Med Chem, (2020) 63:10:5102 | ||||
BMX
Cytoplasmic tyrosine-protein kinase BMX
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.22 | INHIBITOR | ||||