thiram
Ligand Summary
A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.
UNII: 0D771IS0FH
PubChem: 5455
ChEMBL: CHEMBL120563
DrugCentral: 3601
LyCHI: T54GTR939786
Target Activities
MGLL
Monoglyceride lipase
2 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.01 | J. Med. Chem., (2009) 52:22:7310 | ||||
IC50 | 6.01 | |||||
EHMT2
Histone-lysine N-methyltransferase EHMT2
2 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.26 | Bioorg Med Chem Lett, (2018) 28:7:1234 | ||||
IC50 | 6.26 | |||||
LOXL4
Lysyl oxidase homolog 4
2 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.75 | Bioorg Med Chem Lett, (2018) 28:18:3113 | ||||
IC50 | 6.75 | |||||
LOXL3
Lysyl oxidase homolog 3
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.96 | Bioorg Med Chem Lett, (2018) 28:18:3113 | ||||
IC50 | 6.96 | |||||
LOXL2
Lysyl oxidase homolog 2
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.77 | Bioorg Med Chem Lett, (2018) 28:18:3113 | ||||
IC50 | 6.77 | |||||
MDM2
E3 ubiquitin-protein ligase Mdm2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 6.75 | None, None:None:None | ||||