thioridazine
A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
Ligand Summary
UNII: N3D6TG58NI
PubChem: 5452
Guide to Pharmacology: 100
ChEMBL: CHEMBL479
DrugCentral: 2637
LyCHI: NWN99PURSF1L
Target Activities
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10
1 – 10 of 23
KCNH2
Potassium voltage-gated channel subfamily H member 2
11 Activities
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1 – 10 of 11
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.8 | None, None:None:None | ||||
Ki | 5.89 | None, None:None:None | ||||
Ki | 6.06 | Bioorg. Med. Chem. Lett., (2006) 16:20:5303 | ||||
IC50 | 6.44 | Bioorg. Med. Chem., (2008) 16:11:6252 | ||||
IC50 | 6.44 | Bioorg. Med. Chem. Lett., (2003) 13:16:2773 | ||||
IC50 | 6.72 | J. Med. Chem., (2003) 46:11:2017 | ||||
IC50 | 6.72 | Bioorg. Med. Chem. Lett., (2005) 15:11:2886 | ||||
IC50 | 7.02 | Eur. J. Med. Chem., (2011) 46:2:618 | ||||
IC50 | 7.45 | Eur. J. Med. Chem., (2009) 44:5:1926 | ||||
IC50 | 7.48 | J. Med. Chem., (2009) 52:14:4266 | ||||
HTR6
5-hydroxytryptamine receptor 6
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.15 | None, None:None:None | ||||
Ki | 7.48 | None, None:None:None | ||||
7.2 | ||||||
8.2 | ||||||
Ki | 7.2 | ANTAGONIST | ||||
DRD2
D(2) dopamine receptor
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.46 | None, None:None:None | ||||
Ki | 7.57 | J. Med. Chem., (2003) 46:11:2017 | ||||
Ki | 7.92 | None, None:None:None | ||||
IC50 | 7.4 | ANTAGONIST | ||||
HTR7
5-hydroxytryptamine receptor 7
3 Activities
HRH1
Histamine H1 receptor
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.14 | None, None:None:None | ||||
Ki | 8.07 | None, None:None:None | ||||
7.7 | ||||||
HTR2C
5-hydroxytryptamine receptor 2C
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.36 | None, None:None:None | ||||
Ki | 7.64 | None, None:None:None | ||||
CHRM3
Muscarinic acetylcholine receptor M3
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.05 | None, None:None:None | ||||
Ki | 7.72 | None, None:None:None | ||||
CHRM1
Muscarinic acetylcholine receptor M1
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.15 | None, None:None:None | ||||
Ki | 8.77 | None, None:None:None | ||||
ADRA1D
Alpha-1D adrenergic receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.23 | None, None:None:None | ||||
Ki | 8.54 | None, None:None:None | ||||
CHRM4
Muscarinic acetylcholine receptor M4
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.1 | None, None:None:None | ||||
Ki | 7.96 | None, None:None:None | ||||