thioridazine
A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
Ligand Summary
UNII: N3D6TG58NI
PubChem: 5452
Guide to Pharmacology: 100
ChEMBL: CHEMBL479
DrugCentral: 2637
LyCHI: NWN99PURSF1L
Target Activities
KCNH2
Potassium voltage-gated channel subfamily H member 2
14 Activities
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1 – 10 of 14
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.48 | J. Med. Chem., (2009) 52:14:4266 | ||||
IC50 | 7.48 | J. Med. Chem., (2009) 52:14:4266 | ||||
IC50 | 7.48 | Cardiovasc. Res., (2011) 91:None:53 | ||||
IC50 | 7.45 | J. Med. Chem., (2002) 45:18:3844 | ||||
IC50 | 7.45 | Bioorg. Med. Chem. Lett., (2005) 15:6:1737 | ||||
IC50 | 7.45 | Eur. J. Med. Chem., (2009) 44:5:1926 | ||||
IC50 | 7.02 | Eur. J. Med. Chem., (2011) 46:2:618 | ||||
IC50 | 6.72 | J. Med. Chem., (2003) 46:11:2017 | ||||
IC50 | 6.72 | Bioorg. Med. Chem. Lett., (2005) 15:11:2886 | ||||
IC50 | 6.44 | Bioorg. Med. Chem. Lett., (2003) 13:16:2773 | ||||
HTR6
5-hydroxytryptamine receptor 6
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
7.2 | ||||||
8.2 | ||||||
Ki | 7.48 | None, None:None:None | ||||
IC50 | 7.15 | None, None:None:None | ||||
Ki | 7.2 | ANTAGONIST | ||||
DRD2
D(2) dopamine receptor
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.92 | None, None:None:None | ||||
Ki | 7.57 | J. Med. Chem., (2003) 46:11:2017 | ||||
IC50 | 7.46 | None, None:None:None | ||||
IC50 | 7.4 | ANTAGONIST | ||||
HTR7
5-hydroxytryptamine receptor 7
3 Activities
HRH1
Histamine H1 receptor
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
7.7 | ||||||
Ki | 8.07 | None, None:None:None | ||||
IC50 | 7.14 | None, None:None:None | ||||
DRD1
D(1A) dopamine receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
7 | ||||||
Ki | 7.01 | None, None:None:None | ||||
CHRM3
Muscarinic acetylcholine receptor M3
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.72 | None, None:None:None | ||||
IC50 | 7.05 | None, None:None:None | ||||
CHRM4
Muscarinic acetylcholine receptor M4
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.96 | None, None:None:None | ||||
IC50 | 7.1 | None, None:None:None | ||||
DRD3
D(3) dopamine receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.47 | None, None:None:None | ||||
IC50 | 8.01 | None, None:None:None | ||||
CHRM1
Muscarinic acetylcholine receptor M1
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.77 | None, None:None:None | ||||
IC50 | 8.15 | None, None:None:None | ||||
SIGMAR1
Sigma non-opioid intracellular receptor 1
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 6.82 | None, None:None:None | ||||
IC50 | 6.44 | None, None:None:None | ||||
SLC6A4
Sodium-dependent serotonin transporter
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 6.4 | None, None:None:None | ||||
IC50 | 6.12 | None, None:None:None | ||||
ADRA1D
Alpha-1D adrenergic receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.54 | None, None:None:None | ||||
IC50 | 8.23 | None, None:None:None | ||||
HTR2A
5-hydroxytryptamine receptor 2A
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.9 | None, None:None:None | ||||
IC50 | 8.36 | None, None:None:None | ||||
HTR2C
5-hydroxytryptamine receptor 2C
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.64 | None, None:None:None | ||||
IC50 | 7.36 | None, None:None:None | ||||
CHRM5
Muscarinic acetylcholine receptor M5
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.18 | None, None:None:None | ||||
IC50 | 8.03 | None, None:None:None | ||||
HTR1A
5-hydroxytryptamine receptor 1A
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
7.1 | ||||||
DRD5
D(1B) dopamine receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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5.6 | ||||||
KCNJ6
G protein-activated inward rectifier potassium channel 2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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4.2 | ||||||
HTR2B
5-hydroxytryptamine receptor 2B
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.09 | None, None:None:None | ||||
ADRA2A
Alpha-2A adrenergic receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.3 | None, None:None:None | ||||
CACNA1C
Voltage-dependent L-type calcium channel subunit alpha-1C
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 5.88 | Journal of Applied Toxicology, (2012) 32:None:858 | ||||
SCN5A
Sodium channel protein type 5 subunit alpha
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 5.74 | Cardiovasc. Res., (2011) 91:None:53 | ||||
ADRA2C
Alpha-2C adrenergic receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.6 | None, None:None:None | ||||
CHRM2
Muscarinic acetylcholine receptor M2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.42 | None, None:None:None | ||||