Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

KCNH2

Tclin

Potassium voltage-gated channel subfamily H member 2

14 Activities

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1 – 10 of 14

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.48	J. Med. Chem., (2009) 52:14:4266	19534531

IC50	7.48	J. Med. Chem., (2009) 52:14:4266	19534531

IC50	7.48	Cardiovasc. Res., (2011) 91:None:53	21300721

IC50	7.45	J. Med. Chem., (2002) 45:18:3844	12190308

IC50	7.45	Bioorg. Med. Chem. Lett., (2005) 15:6:1737	15745831

IC50	7.45	Eur. J. Med. Chem., (2009) 44:5:1926	19110341

IC50	7.02	Eur. J. Med. Chem., (2011) 46:2:618	21185626

IC50	6.72	J. Med. Chem., (2003) 46:11:2017	12747773

IC50	6.72	Bioorg. Med. Chem. Lett., (2005) 15:11:2886	15911273

IC50	6.44	Bioorg. Med. Chem. Lett., (2003) 13:16:2773	12873512

HTR6

Tchem

5-hydroxytryptamine receptor 6

5 Activities

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1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	7.2			15821958

	8.2			7908055

Ki	7.48		None, None:None:None

IC50	7.15		None, None:None:None

Ki	7.2	ANTAGONIST	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=100

DRD2

Tclin

D(2) dopamine receptor

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.92		None, None:None:None

Ki	7.57		J. Med. Chem., (2003) 46:11:2017	12747773

IC50	7.46		None, None:None:None

IC50	7.4	ANTAGONIST	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL479

HTR7

Tclin

5-hydroxytryptamine receptor 7

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
	7.1		15821958

	7.2		7908055

Ki	7.16	J. Med. Chem., (2003) 46:14:2795	12825922

HRH1

Tclin

Histamine H1 receptor

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
	7.7		12629531

Ki	8.07	None, None:None:None

IC50	7.14	None, None:None:None

DRD1

Tclin

D(1A) dopamine receptor

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
	7		1826762

Ki	7.01	None, None:None:None

CHRM3

Tclin

Muscarinic acetylcholine receptor M3

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	7.72	None, None:None:None

IC50	7.05	None, None:None:None

CHRM4

Tclin

Muscarinic acetylcholine receptor M4

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	7.96	None, None:None:None

IC50	7.1	None, None:None:None

DRD3

Tclin

D(3) dopamine receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	8.47	None, None:None:None

IC50	8.01	None, None:None:None

CHRM1

Tclin

Muscarinic acetylcholine receptor M1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	8.77	None, None:None:None

IC50	8.15	None, None:None:None

SIGMAR1

Tclin

Sigma non-opioid intracellular receptor 1

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	6.82	None, None:None:None

IC50	6.44	None, None:None:None

SLC6A4

Tclin

Sodium-dependent serotonin transporter

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	6.4	None, None:None:None

IC50	6.12	None, None:None:None

ADRA1D

Tclin

Alpha-1D adrenergic receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	8.54	None, None:None:None

IC50	8.23	None, None:None:None

HTR2A

Tclin

5-hydroxytryptamine receptor 2A

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	8.9	None, None:None:None

IC50	8.36	None, None:None:None

HTR2C

Tclin

5-hydroxytryptamine receptor 2C

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	7.64	None, None:None:None

IC50	7.36	None, None:None:None

CHRM5

Tclin

Muscarinic acetylcholine receptor M5

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	8.18	None, None:None:None

IC50	8.03	None, None:None:None

HTR1A

Tclin

5-hydroxytryptamine receptor 1A

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	7.1			9760039

DRD5

Tchem

D(1B) dopamine receptor

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	5.6			1826762

KCNJ6

Tchem

G protein-activated inward rectifier potassium channel 2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	4.2			10780978

HTR2B

Tclin

5-hydroxytryptamine receptor 2B

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.09		None, None:None:None

ADRA2A

Tclin

Alpha-2A adrenergic receptor

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.3		None, None:None:None

CACNA1C

Tclin

Voltage-dependent L-type calcium channel subunit alpha-1C

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	5.88		Journal of Applied Toxicology, (2012) 32:None:858	22761000

SCN5A

Tclin

Sodium channel protein type 5 subunit alpha

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	5.74		Cardiovasc. Res., (2011) 91:None:53	21300721

ADRA2C

Tclin

Alpha-2C adrenergic receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.6		None, None:None:None

CHRM2

Tclin

Muscarinic acetylcholine receptor M2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.42		None, None:None:None