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thalidomide

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
Synonyms & Links
PubChem: 5426
DrugCentral: 2616
LyCHI:  RFRZDXFY6BYS