You are using an outdated browser. Please upgrade your browser to improve your experience.

teniposide

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
Synonyms & Links
DrugCentral: 2590
LyCHI:  CRN1Z4N84WYV