tacrine
A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
Ligand Summary
UNII: 4VX7YNB537
PubChem: 1935
PubChem: 135504745
PubChem: 115097
Guide to Pharmacology: 6687
ChEMBL: CHEMBL95
ChEMBL: CHEMBL1677
ChEMBL: CHEMBL263198
DrugCentral: 2551
LyCHI: 5L7ZPW8RPXA9
Target Activities
ACHE
Acetylcholinesterase
131 Activities
Items per page:
1 – 10 of 131
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.03 | J. Med. Chem., (2007) 50:23:5685 | ||||
IC50 | 6.1 | J. Med. Chem., (2010) 53:17:6490 | ||||
IC50 | 6.27 | J. Med. Chem., (2013) 56:22:9089 | ||||
IC50 | 6.27 | Bioorg. Med. Chem., (2014) 22:4:1355 | ||||
IC50 | 6.28 | Bioorg. Med. Chem., (2013) 21:17:4928 | ||||
IC50 | 6.3 | Eur. J. Med. Chem., (2012) 55:None:23 | ||||
IC50 | 6.3 | Bioorg. Med. Chem. Lett., (2011) 21:21:6563 | ||||
IC50 | 6.3 | J. Med. Chem., (2014) 57:16:7073 | ||||
IC50 | 6.3 | J. Med. Chem., (2014) 57:20:8576 | ||||
IC50 | 6.3 | Bioorg. Med. Chem., (2015) 23:17:5610 | ||||
BCHE
Cholinesterase
80 Activities
Items per page:
1 – 10 of 80
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.05 | J. Med. Chem., (2002) 45:11:2277 | ||||
IC50 | 7.1 | J. Med. Chem., (2015) 58:22:8985 | ||||
IC50 | 7.14 | Eur. J. Med. Chem., (2011) 46:6:2193 | ||||
IC50 | 7.14 | Bioorg. Med. Chem. Lett., (2015) 25:4:830 | ||||
IC50 | 7.24 | J. Med. Chem., (2007) 50:22:5311 | ||||
IC50 | 7.24 | Bioorg. Med. Chem. Lett., (2013) 23:23:6254 | ||||
IC50 | 7.27 | J. Med. Chem., (2003) 46:6:954 | ||||
IC50 | 7.3 | Eur. J. Med. Chem., (2011) 46:9:4336 | ||||
IC50 | 7.3 | Eur. J. Med. Chem., (2014) 75:None:21 | ||||
IC50 | 7.33 | J. Med. Chem., (2005) 48:4:986 | ||||
SLC6A2
Sodium-dependent noradrenaline transporter
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.29 | None, None:None:None | ||||
Ki | 6.29 | None, None:None:None | ||||
CHRNE
Acetylcholine receptor subunit epsilon
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.36 | J. Med. Chem., (2005) 48:23:7496 | ||||
APP
Amyloid-beta A4 protein
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.91 | Eur. J. Med. Chem., (2016) 116:None:200 | ||||
CYP2D6
Cytochrome P450 2D6
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.52 | None, None:None:None | ||||
CHRM1
Muscarinic acetylcholine receptor M1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.69999981 | |||||
CHRM2
Muscarinic acetylcholine receptor M2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.67999983 | |||||