Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

KDR

Tclin

Vascular endothelial growth factor receptor 2

34 Activities

Items per page:

1 – 10 of 34

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.05		15466206

Kd	7.23		22037378

Ki	10.68	Bioorg. Med. Chem., (2011) 19:18:5342	21885287

Ki	9.92	Bioorg. Med. Chem., (2011) 19:18:5342	21885287

IC50	9.8	Bioorg. Med. Chem., (2011) 19:18:5342	21885287

IC50	9.77	Eur J Med Chem, (2019) 163:None:1	30503935

IC50	9.77	Eur J Med Chem, (2019) 164:None:440	30616052

IC50	9.35	Eur J Med Chem, (2017) 127:None:275	28068599

IC50	9.32	Bioorg. Med. Chem., (2015) 23:13:3228	25982075

IC50	9.32	Eur. J. Med. Chem., (2015) 103:None:80	26342134

BRAF

Tclin

Serine/threonine-protein kinase B-raf

25 Activities

Items per page:

1 – 10 of 25

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.66		15466206

IC50	9	J. Med. Chem., (2008) 51:22:7049	18942827

IC50	9	Bioorg. Med. Chem. Lett., (2011) 21:4:1248	21211972

EC50	8.52	Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936	18077425

IC50	8.36	J Med Chem, (2018) 61:14:5775	29461827

IC50	7.92	Eur. J. Med. Chem., (2014) 87:None:782	25440879

IC50	7.92	Eur. J. Med. Chem., (2014) 85:None:215	25086238

IC50	7.9	None, (2015) None:None:None

IC50	7.89	Bioorg. Med. Chem. Lett., (2013) 23:13:3732	23726028

IC50	7.85	Bioorg. Med. Chem. Lett., (2008) 18:9:2825	18434146

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

25 Activities

Items per page:

1 – 10 of 25

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.24		15466206

IC50	8.89	Eur J Med Chem, (2019) 176:None:248	31103903

IC50	8.7	Blood, (2009) 114:14:2984	19654408

IC50	8.7	J. Med. Chem., (2014) 57:8:3430	24641103

IC50	8.49	Blood, (2009) 114:14:2984	19654408

IC50	8.4	J. Med. Chem., (2014) 57:8:3430	24641103

Kd	8.35	Blood, (2009) 114:14:2984	19654408

Kd	8.35	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.15	J. Med. Chem., (2013) 56:4:1641	23362959

Kd	7.96	Nat. Biotechnol., (2008) 26:1:127	18183025

RAF1

Tclin

RAF proto-oncogene serine/threonine-protein kinase

20 Activities

Items per page:

1 – 10 of 20

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.22		15466206

IC50	9	J. Med. Chem., (2008) 51:22:7049	18942827

IC50	8.52	Bioorg. Med. Chem. Lett., (2008) 18:9:2825	18434146

Ki	8.22	J. Med. Chem., (2008) 51:19:6121	18783202

IC50	8.22	J. Med. Chem., (2010) 53:4:1413	20166671

IC50	8.22	Bioorg. Med. Chem. Lett., (2010) 20:19:5722	20797858

IC50	8.22	J. Med. Chem., (2011) 54:6:1836	21341678

IC50	8.22	J. Med. Chem., (2012) 55:17:7332	22808911

IC50	8.22	Eur. J. Med. Chem., (2014) 87:None:782	25440879

IC50	8.22	Eur. J. Med. Chem., (2014) 85:None:215	25086238

KIT

Tclin

Mast/stem cell growth factor receptor Kit

13 Activities

Items per page:

1 – 10 of 13

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.17		15466206

IC50	8	J. Med. Chem., (2008) 51:22:7049	18942827

Kd	7.96	Blood, (2009) 114:14:2984	19654408

Kd	7.8	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.8	Blood, (2009) 114:14:2984	19654408

Kd	7.8	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.75	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.75	Blood, (2009) 114:14:2984	19654408

Kd	7.75	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.7	Nat. Biotechnol., (2011) 29:11:1046	22037378

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.9		23279183

IC50	8.22	J. Med. Chem., (2015) 58:9:3672	25625428

Kd	8.13	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.13	Blood, (2009) 114:14:2984	19654408

Kd	8.13	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.05	Nat. Chem. Biol., (2008) 4:11:691	18849971

Kd	7.89	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.89	Blood, (2009) 114:14:2984	19654408

Kd	7.89	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.66	Blood, (2009) 114:14:2984	19654408

DDR2

Tchem

Discoidin domain-containing receptor 2

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8		23279183

Kd	8.18	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.18	Blood, (2009) 114:14:2984	19654408

Kd	8.18	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.18	J. Med. Chem., (2015) 58:8:3287	25569119

IC50	8.15	J. Med. Chem., (2014) 57:10:4252	24754677

Kd	8.15	J. Med. Chem., (2014) 57:10:4252	24754677

Kd	8.18	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

FLT4

Tclin

Vascular endothelial growth factor receptor 3

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.7			15466206

IC50	8.52		Bioorg. Med. Chem., (2010) 18:13:4674	20570526

Kd	7.8		Nat. Biotechnol., (2005) 23:3:329	15711537

Kd	7.8		Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936	18077425

IC50	7.8		J. Med. Chem., (2012) 55:12:5749	22694093

Kd	7.8	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

PDGFRB

Tclin

Platelet-derived growth factor receptor beta

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.24			15466206

Ki	8.4		None, None:None:None

IC50	8		J. Med. Chem., (2008) 51:22:7049	18942827

IC50	7.74		None, (2016) None:None:None

Kd	7.43	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

EPHX2

Tchem

Bifunctional epoxide hydrolase 2

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	9.3	None, (2015) None:None:None

IC50	9.3	None, (2015) None:None:None

IC50	7.92	Bioorg. Med. Chem. Lett., (2013) 23:13:3732	23726028

IC50	7.92	None, (2015) None:None:None

IC50	7.92	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

MAP3K20

Tchem

Mitogen-activated protein kinase kinase kinase 20

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.2	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.2	Blood, (2009) 114:14:2984	19654408

Kd	8.2	Nat. Biotechnol., (2011) 29:11:1046	22037378

Ki	7.8	None, None:None:None

Kd	8.2	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

DDR1

Tchem

Epithelial discoidin domain-containing receptor 1

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.82	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.82	Blood, (2009) 114:14:2984	19654408

Kd	8.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.82	J. Med. Chem., (2015) 58:8:3287	25569119

Kd	8.82	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

TEK

Tclin

Angiopoietin-1 receptor

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	9.41	Eur J Med Chem, (2019) 163:None:1	30503935

IC50	9.41	Eur J Med Chem, (2019) 164:None:440	30616052

IC50	9.08	Eur J Med Chem, (2017) 127:None:275	28068599

IC50	8.17	Eur J Med Chem, (2017) 141:None:506	29102175

IC50	8.11	Eur J Med Chem, (2017) 141:None:373	29032031

EPHB4

Tchem

Ephrin type-B receptor 4

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	9.7	Eur J Med Chem, (2017) 127:None:275	28068599

IC50	9.66	Eur J Med Chem, (2019) 163:None:1	30503935

IC50	9.66	Eur J Med Chem, (2019) 164:None:440	30616052

IC50	8.35	Eur J Med Chem, (2017) 141:None:506	29102175

IC50	8.34	Eur J Med Chem, (2017) 141:None:373	29032031

CSF1R

Tclin

Macrophage colony-stimulating factor 1 receptor

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.72	J. Med. Chem., (2008) 51:22:7049	18942827

Kd	7.55	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.55	Blood, (2009) 114:14:2984	19654408

Kd	7.55	Nat. Biotechnol., (2011) 29:11:1046	22037378

ARAF

Tchem

Serine/threonine-protein kinase A-Raf

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.15	Eur J Med Chem, (2017) 130:None:86	28242553

IC50	8.15	Eur J Med Chem, (2019) 163:None:243	30529543

IC50	7.92	Bioorg Med Chem Lett, (2019) 29:13:1605	31053508

IC50	8.15	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

HIPK4

Tchem

Homeodomain-interacting protein kinase 4

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.57	Blood, (2009) 114:14:2984	19654408

Kd	8.48	Nat. Biotechnol., (2011) 29:11:1046	22037378

Ki	8	None, None:None:None

Kd	8.57	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

FGFR1

Tclin

Fibroblast growth factor receptor 1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.24		15466206

IC50	8.33	Bioorg. Med. Chem., (2016) 24:4:750	26753815

FLT1

Tclin

Vascular endothelial growth factor receptor 1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.75		Bioorg. Med. Chem., (2011) 19:14:4173	21708468

Kd	7.51	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

MAPK3

Tchem

Mitogen-activated protein kinase 3

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.74	Eur. J. Med. Chem., (2015) 94:None:397	25778995

IC50	7.74	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

CDK19

Tchem

Cyclin-dependent kinase 19

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	6.99			26502155

CDK8

Tchem

Cyclin-dependent kinase 8

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7			26502155

HTR2B

Tclin

5-hydroxytryptamine receptor 2B

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.25		J. Med. Chem., (2012) 55:12:5749	22694093

EGFR

Tclin

Epidermal growth factor receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.53		Bioorg. Med. Chem., (2016) 24:4:750	26753815

MAPK14

Tchem

Mitogen-activated protein kinase 14

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.8		None, None:None:None