Pharos : Ligand Details

Target Activities

KDR

Tclin

Vascular endothelial growth factor receptor 2

24 Activities

Items per page:

1 – 10 of 24

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.57	Nat. Chem. Biol., (2008) 4:11:691	18849971

IC50	7.64	Bioorg. Med. Chem., (2011) 19:18:5342	21885287

Ki	7.66	Bioorg. Med. Chem., (2011) 19:18:5342	21885287

IC50	7.66	Eur. J. Med. Chem., (2012) 53:None:254	22560627

IC50	7.7	Bioorg. Med. Chem., (2013) 21:11:2856	23618709

IC50	7.7	Bioorg. Med. Chem. Lett., (2012) 22:14:4654	22726931

IC50	7.9	Eur. J. Med. Chem., (2014) 72:None:146	24368209

IC50	7.96	None, (2016) None:None:None

IC50	8	Eur. J. Med. Chem., (2016) 109:None:371	26826581

IC50	8.21	Bioorg. Med. Chem., (2011) 19:18:5342	21885287

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

19 Activities

Items per page:

1 – 10 of 19

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.7	Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936	18077425

Kd	7.7	Nat. Biotechnol., (2005) 23:3:329	15711537

Kd	7.77	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.89	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.89	MedChemComm, (2016) 7:3:484

Kd	7.89	Blood, (2009) 114:14:2984	19654408

Kd	7.89	Blood, (2009) 114:14:2984	19654408

Kd	7.89	J. Med. Chem., (2009) 52:23:7808	19754199

Kd	7.89	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.96	Nat. Biotechnol., (2008) 26:1:127	18183025

RAF1

Tclin

RAF proto-oncogene serine/threonine-protein kinase

16 Activities

Items per page:

1 – 10 of 16

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.61	Bioorg. Med. Chem., (2012) 20:14:4323	22721924

IC50	7.66	Eur. J. Med. Chem., (2014) 77:None:351	24675135

IC50	7.92	Eur. J. Med. Chem., (2009) 44:3:1240	18947905

IC50	7.92	Bioorg. Med. Chem. Lett., (2004) 14:3:783	14741289

Ki	8.22	J. Med. Chem., (2008) 51:19:6121	18783202

IC50	8.22	Bioorg. Med. Chem. Lett., (2010) 20:19:5722	20797858

IC50	8.22	J. Med. Chem., (2011) 54:6:1836	21341678

IC50	8.22	J. Med. Chem., (2012) 55:17:7332	22808911

IC50	8.22	Eur. J. Med. Chem., (2014) 85:None:215	25086238

IC50	8.22	Eur. J. Med. Chem., (2016) 115:None:201	27017549

BRAF

Tclin

Serine/threonine-protein kinase B-raf

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.58	Eur. J. Med. Chem., (2015) 89:None:581	25462267

Ki	7.66	Chem. Biol., (2005) 12:6:621	15975507

IC50	7.66	Bioorg. Med. Chem. Lett., (2011) 21:23:6941	22024030

IC50	7.66	J. Med. Chem., (2012) 55:17:7332	22808911

IC50	7.66	Nat. Chem. Biol., (2006) 2:7:358	16783341

IC50	7.82	Bioorg. Med. Chem. Lett., (2008) 18:9:2825	18434146

IC50	7.9	None, (2015) None:None:None

IC50	7.92	Eur. J. Med. Chem., (2014) 85:None:215	25086238

IC50	7.92	Eur. J. Med. Chem., (2014) 87:None:782	25440879

EC50	8.52	Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936	18077425

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.66		Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.89		Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.89		Blood, (2009) 114:14:2984	19654408

Kd	7.89		Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.05		Nat. Chem. Biol., (2008) 4:11:691	18849971

Kd	8.13		Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.13		Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.22		J. Med. Chem., (2015) 58:9:3672	25625428

IC50	7.9000001			23279183

Kd	8.13	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

KIT

Tclin

Mast/stem cell growth factor receptor Kit

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.55		Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.6		Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.7		Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.75		Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.75		Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.8		Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.8		Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8		J. Med. Chem., (2008) 51:22:7049	18942827

IC50	7.17000008			15466206

Kd	7.8	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

DDR2

Tchem

Discoidin domain-containing receptor 2

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.15	J. Med. Chem., (2014) 57:10:4252	24754677

Kd	8.15	J. Med. Chem., (2014) 57:10:4252	24754677

Kd	8.18	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.18	Blood, (2009) 114:14:2984	19654408

Kd	8.18	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.18	J. Med. Chem., (2015) 58:8:3287	25569119

IC50	8		23279183

Kd	8.18	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

FLT4

Tclin

Vascular endothelial growth factor receptor 3

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.8		Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936	18077425

Kd	7.8		Nat. Biotechnol., (2005) 23:3:329	15711537

IC50	7.8		J. Med. Chem., (2012) 55:12:5749	22694093

IC50	8.52		Bioorg. Med. Chem., (2010) 18:13:4674	20570526

IC50	7.69999981			15466206

Kd	7.8	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

DDR1

Tchem

Epithelial discoidin domain-containing receptor 1

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.82	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.82	Blood, (2009) 114:14:2984	19654408

Kd	8.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.82	J. Med. Chem., (2015) 58:8:3287	25569119

Kd	8.82	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

CSF1R

Tclin

Macrophage colony-stimulating factor 1 receptor

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.55	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.55	Blood, (2009) 114:14:2984	19654408

Kd	7.55	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.72	J. Med. Chem., (2008) 51:22:7049	18942827

MAP3K20

Tchem

Mitogen-activated protein kinase kinase kinase 20

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.2	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.2	Blood, (2009) 114:14:2984	19654408

Kd	8.2	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.2	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

EPHX2

Tchem

Bifunctional epoxide hydrolase 2

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.92	None, (2015) None:None:None

IC50	7.92	None, (2015) None:None:None

IC50	7.92	Bioorg. Med. Chem. Lett., (2013) 23:13:3732	23726028

IC50	7.92	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

PDGFRB

Tclin

Platelet-derived growth factor receptor beta

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.74		None, (2016) None:None:None

IC50	8		J. Med. Chem., (2008) 51:22:7049	18942827

IC50	7.23999977			15466206

Kd	7.43	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

HIPK4

Tchem

Homeodomain-interacting protein kinase 4

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.48	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.57	Blood, (2009) 114:14:2984	19654408

Kd	8.57	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

MAPK3

Tchem

Mitogen-activated protein kinase 3

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.74	Eur. J. Med. Chem., (2015) 94:None:397	25778995

IC50	7.74	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

FGFR1

Tclin

Fibroblast growth factor receptor 1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.33	Bioorg. Med. Chem., (2016) 24:4:750	26753815

IC50	6.23999977		15466206

FLT1

Tclin

Vascular endothelial growth factor receptor 1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.75		Bioorg. Med. Chem., (2011) 19:14:4173	21708468

Kd	7.51	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1336

EGFR

Tclin

Epidermal growth factor receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.53		Bioorg. Med. Chem., (2016) 24:4:750	26753815

HTR2B

Tclin

5-hydroxytryptamine receptor 2B

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.25		J. Med. Chem., (2012) 55:12:5749	22694093

CDK19

Tchem

Cyclin-dependent kinase 19

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	6.98999977			26502155

CDK8

Tchem

Cyclin-dependent kinase 8

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7			26502155