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siponimod

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Siponimod is a sphingosine-1-phosphate (S1P) receptor modulator. Siponimod binds with high affinity to S1P receptors 1 and 5. Siponimod blocks the capacity of lymphocytes to egress from lymph nodes, reducing the number of lymphocytes in peripheral blood. The mechanism by which siponimod exerts therapeutic effects in multiple sclerosis is unknown, but may involve reduction of lymphocyte migration into the central nervous system.
Synonyms & Links
Guide to Pharmacology: 9289
DrugCentral: 5326
LyCHI:  MNH4Z54W3PQH


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Target Activities