siponimod
Siponimod is a sphingosine-1-phosphate (S1P) receptor modulator. Siponimod binds with high affinity to S1P receptors 1 and 5. Siponimod blocks the capacity of lymphocytes to egress from lymph nodes, reducing the number of lymphocytes in peripheral blood. The mechanism by which siponimod exerts therapeutic effects in multiple sclerosis is unknown, but may involve reduction of lymphocyte migration into the central nervous system.
Ligand Summary
UNII: RR6P8L282I
PubChem: 44599207
Guide to Pharmacology: 9289
ChEMBL: CHEMBL2336071
DrugCentral: 5326
LyCHI: MNH4Z54W3PQH
Target Activities
S1PR1
Sphingosine 1-phosphate receptor 1
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 9.4 | |||||
EC50 | 9.4 | ACS Med. Chem. Lett., (2013) 4:3:333 | ||||
EC50 | 9.41 | MODULATOR | ||||
S1PR5
Sphingosine 1-phosphate receptor 5
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 9.01 | |||||
EC50 | 9.01 | Bioorg. Med. Chem. Lett., (2013) 23:23:6377 | ||||
EC50 | 9.01 | MODULATOR | ||||
S1PR3
Sphingosine 1-phosphate receptor 3
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 5.3 | |||||
S1PR4
Sphingosine 1-phosphate receptor 4
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 6.12 | |||||