simvastatin
Ligand Summary
A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
UNII: AGG2FN16EV
PubChem: 54454
Guide to Pharmacology: 2955
ChEMBL: CHEMBL1064
DrugCentral: 2445
LyCHI: NZ548L771W7J
Target Activities
16 Activities
Items per page:
1 – 10 of 16
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