safinamide
Ligand Summary
Safinamide acts through both dopaminergic and non-dopaminergic mechanisms of action. Safinamide is a highly selective and reversible MAO-B inhibitor causing an increase in extracellular levels of dopamine in the striatum. Safinamide is associated with state-dependent inhibition of voltage-gated sodium (Na+) channels, and modulation of stimulated release of glutamate. To what extent the nondopaminergic effects contribute to the overall effect has not been established.
UNII: 90ENL74SIG
PubChem: 131682
Guide to Pharmacology: 8291
ChEMBL: CHEMBL396778
DrugCentral: 4921
LyCHI: DTWNHFHALMXH
Target Activities
45 Activities
Items per page:
10
1 – 10 of 45
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