rufinamide
The precise mechanism(s) by which rufinamide exerts its antiepileptic effect is unknown. The results of in vitro studies suggest that the principal mechanism of action of rufinamide is modulation of the activity of sodium channels and, in particular, prolongation of the inactive state of the channel.
Ligand Summary
UNII: WFW942PR79
PubChem: 129228
ChEMBL: CHEMBL1201754
DrugCentral: 3534
LyCHI: 89D44GBLRPKK
Target Activities
CA5A
Carbonic anhydrase 5A, mitochondrial
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Ki | 6.46 | Eur J Med Chem, (2019) 181:None:111565 | ||||
SCN1A
Sodium channel protein type 1 subunit alpha
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BLOCKER | ||||||
SCN4A
Sodium channel protein type 4 subunit alpha
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BLOCKER | ||||||
SCN7A
Sodium channel protein type 7 subunit alpha
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BLOCKER | ||||||
SCN5A
Sodium channel protein type 5 subunit alpha
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BLOCKER | ||||||
SCN9A
Sodium channel protein type 9 subunit alpha
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BLOCKER | ||||||
SCN2A
Sodium channel protein type 2 subunit alpha
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BLOCKER | ||||||
SCN3A
Sodium channel protein type 3 subunit alpha
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BLOCKER | ||||||
SCN11A
Sodium channel protein type 11 subunit alpha
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BLOCKER | ||||||
SCN8A
Sodium channel protein type 8 subunit alpha
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BLOCKER | ||||||
SCN10A
Sodium channel protein type 10 subunit alpha
1 Activities
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BLOCKER | ||||||