rufinamide
The precise mechanism(s) by which rufinamide exerts its antiepileptic effect is unknown. The results of in vitro studies suggest that the principal mechanism of action of rufinamide is modulation of the activity of sodium channels and, in particular, prolongation of the inactive state of the channel.
Ligand Summary
Target Activities
SCN1A
Sodium channel protein type 1 subunit alpha
1 Activities
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BLOCKER | ||||||
SCN4A
Sodium channel protein type 4 subunit alpha
1 Activities
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BLOCKER | ||||||
SCN7A
Sodium channel protein type 7 subunit alpha
1 Activities
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BLOCKER | ||||||
SCN5A
Sodium channel protein type 5 subunit alpha
1 Activities
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BLOCKER | ||||||
SCN9A
Sodium channel protein type 9 subunit alpha
1 Activities
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BLOCKER | ||||||
SCN2A
Sodium channel protein type 2 subunit alpha
1 Activities
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BLOCKER | ||||||
SCN3A
Sodium channel protein type 3 subunit alpha
1 Activities
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BLOCKER | ||||||
SCN11A
Sodium channel protein type 11 subunit alpha
1 Activities
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BLOCKER | ||||||
SCN8A
Sodium channel protein type 8 subunit alpha
1 Activities
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BLOCKER | ||||||
SCN10A
Sodium channel protein type 10 subunit alpha
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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BLOCKER | ||||||