ruboxistaurin
inhibits protein kinase C beta
Ligand Summary
UNII: 721809WQCP
PubChem: 153999
PubChem: 11577725
Guide to Pharmacology: 5263
ChEMBL: CHEMBL91829
ChEMBL: CHEMBL432130
DrugCentral: 3533
LyCHI: HPQ8NT4MYHMB
Target Activities
PRKCB
Protein kinase C beta type
9 Activities
Items per page:
1 – 9 of 9
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.22 | J. Med. Chem., (2003) 46:19:4021 | ||||
IC50 | 8.23 | J. Med. Chem., (1996) 39:14:2664 | ||||
IC50 | 8.23 | Bioorg. Med. Chem. Lett., (2004) 14:20:5171 | ||||
IC50 | 8.23 | Bioorg. Med. Chem. Lett., (2003) 13:11:1857 | ||||
IC50 | 8.33 | J. Med. Chem., (1996) 39:14:2664 | ||||
IC50 | 8.33 | Bioorg. Med. Chem. Lett., (2004) 14:20:5171 | ||||
IC50 | 8.33 | Bioorg. Med. Chem. Lett., (2003) 13:11:1857 | ||||
IC50 | 8.22999954 | |||||
IC50 | 8.33 | |||||
PIM3
Serine/threonine-protein kinase pim-3
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.92 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 7.92 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.92 | |||||
PRKCD
Protein kinase C delta type
3 Activities
PRKCQ
Protein kinase C theta type
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 8.6 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.6 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.6 | |||||
PRKCE
Protein kinase C epsilon type
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.96 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 7.96 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.96 | |||||
PIM1
Serine/threonine-protein kinase pim-1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.69999981 | |||||
PIM2
Serine/threonine-protein kinase pim-2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 4.69999981 | |||||
PRKCA
Protein kinase C alpha type
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.44000006 | |||||
PRKCG
Protein kinase C gamma type
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.51999998 | |||||