rosiglitazone
A thiazolidinedione that functions as a selective agonist for PPAR GAMMA. It improves INSULIN SENSITIVITY in adipose tissue, skeletal muscle, and the liver of patients with TYPE 2 DIABETES MELLITUS.
Ligand Summary
Target Activities
PPARG
Peroxisome proliferator-activated receptor gamma
113 Activities
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1 – 10 of 113
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 6.92 | |||||
- | 7.4 | |||||
EC50 | 9 | None, (2016) None:None:None | ||||
Kd | 8.92 | Eur J Med Chem, (2017) 127:None:379 | ||||
EC50 | 8.62 | J. Med. Chem., (2012) 55:11:4978 | ||||
EC50 | 8.57 | J. Biol. Chem., (2007) 282:23:17314 | ||||
EC50 | 8.42 | J. Biol. Chem., (2007) 282:23:17314 | ||||
EC50 | 8.4 | Bioorg. Med. Chem. Lett., (2005) 15:20:4421 | ||||
EC50 | 8.4 | J. Med. Chem., (2013) 56:4:1535 | ||||
EC50 | 8.4 | Eur J Med Chem, (2017) 137:None:310 | ||||
CISD1
CDGSH iron-sulfur domain-containing protein 1
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.51 | Bioorg Med Chem Lett, (2016) 26:21:5350 | ||||
IC50 | 6.14 | Bioorg Med Chem Lett, (2016) 26:21:5350 | ||||
Ki | 7.51 | |||||
PPARA
Peroxisome proliferator-activated receptor alpha
2 Activities
FFAR1
Free fatty acid receptor 1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
5.6 | ||||||
TRPC5
Short transient receptor potential channel 5
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
- | 4.51 | |||||
MAOB
Amine oxidase [flavin-containing] B
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.08 | Bioorg. Med. Chem. Lett., (2010) 20:17:5295 | ||||