roflumilast
Ligand Summary
UNII: 0P6C6ZOP5U
PubChem: 449193
Guide to Pharmacology: 6962
ChEMBL: CHEMBL193240
DrugCentral: 3531
LyCHI: LAJCMJDNMUA5
Target Activities
PDE4B
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
24 Activities
Items per page:
1 – 10 of 24
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
- | 9.4 | |||||
IC50 | 9.4 | Bioorg. Med. Chem. Lett., (2009) 19:5:1380 | ||||
IC50 | 9.4 | Bioorg. Med. Chem. Lett., (2009) 19:17:5261 | ||||
IC50 | 9.4 | Bioorg. Med. Chem. Lett., (2014) 24:18:4594 | ||||
Ki | 9.4 | J Med Chem, (2018) 61:9:3870 | ||||
IC50 | 9.31 | Bioorg. Med. Chem. Lett., (2013) 23:11:3325 | ||||
IC50 | 9.31 | Bioorg. Med. Chem., (2013) 21:22:7025 | ||||
IC50 | 9.16 | Eur. J. Med. Chem., (2011) 46:10:4946 | ||||
IC50 | 9.16 | J Med Chem, (2016) 59:23:10479 | ||||
IC50 | 9.15 | J Med Chem, (2018) 61:6:2472 | ||||
PDE4D
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
13 Activities
Items per page:
1 – 10 of 13
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 9.7 | Eur J Med Chem, (2019) 174:None:198 | ||||
IC50 | 9.57 | Eur. J. Med. Chem., (2011) 46:10:4946 | ||||
IC50 | 9.4 | J Med Chem, (2019) 62:11:5579 | ||||
IC50 | 9.4 | J Med Chem, (2020) 63:6:3370 | ||||
IC50 | 9.25 | Eur J Med Chem, (2018) 148:None:477 | ||||
IC50 | 9.17 | None, None:None:None | ||||
IC50 | 9.17 | J Med Chem, (2016) 59:15:7029 | ||||
IC50 | 9.17 | |||||
IC50 | 9.15 | Bioorg. Med. Chem. Lett., (2014) 24:18:4594 | ||||
IC50 | 8.96 | Bioorg Med Chem Lett, (2018) 28:7:1188 | ||||
PDE4A
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 9.46 | Bioorg. Med. Chem. Lett., (2013) 23:15:4308 | ||||
IC50 | 9.23 | Eur. J. Med. Chem., (2011) 46:10:4946 | ||||
IC50 | 9.1 | INHIBITOR | ||||
PDE4C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 9.1 | INHIBITOR | ||||