Pharos : Ligand Details - roflumilast

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

UNII: 0P6C6ZOP5U

PubChem: 449193

Guide to Pharmacology: 6962

ChEMBL: CHEMBL193240

DrugCentral: 3531

LyCHI: LAJCMJDNMUA5

Target Activities

Explore Associated and Predicted Targets

PDE4B

Tclin

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

24 Activities

Items per page:

1 – 10 of 24

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
-	9.4			19195882

IC50	9.4		Bioorg. Med. Chem. Lett., (2009) 19:5:1380	19195882

IC50	9.4		Bioorg. Med. Chem. Lett., (2009) 19:17:5261	19656678

IC50	9.4		Bioorg. Med. Chem. Lett., (2014) 24:18:4594	25149511

Ki	9.4		J Med Chem, (2018) 61:9:3870	29672041

IC50	9.31		Bioorg. Med. Chem. Lett., (2013) 23:11:3325	23602400

IC50	9.31		Bioorg. Med. Chem., (2013) 21:22:7025	24094436

IC50	9.16		Eur. J. Med. Chem., (2011) 46:10:4946	21871695

IC50	9.16		J Med Chem, (2016) 59:23:10479	27933955

IC50	9.15		J Med Chem, (2018) 61:6:2472	29502405

PDE4D

Tclin

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

13 Activities

Items per page:

1 – 10 of 13

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9.7		Eur J Med Chem, (2019) 174:None:198	31035240

IC50	9.57		Eur. J. Med. Chem., (2011) 46:10:4946	21871695

IC50	9.4		J Med Chem, (2019) 62:11:5579	31099559

IC50	9.4		J Med Chem, (2020) 63:6:3370	32115956

IC50	9.25		Eur J Med Chem, (2018) 148:None:477	29477888

IC50	9.17		None, None:None:None

IC50	9.17		J Med Chem, (2016) 59:15:7029	26908025

IC50	9.17

IC50	9.15		Bioorg. Med. Chem. Lett., (2014) 24:18:4594	25149511

IC50	8.96		Bioorg Med Chem Lett, (2018) 28:7:1188	29545101

PDE4A

Tclin

cAMP-specific 3',5'-cyclic phosphodiesterase 4A

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9.46		Bioorg. Med. Chem. Lett., (2013) 23:15:4308	23806553

IC50	9.23		Eur. J. Med. Chem., (2011) 46:10:4946	21871695

IC50	9.1	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL193240

PDE4C

Tclin

cAMP-specific 3',5'-cyclic phosphodiesterase 4C

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9.1	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL193240