ritonavir
Ritonavir is a peptidomimetic inhibitor of the HIV-1 protease. Inhibition of HIV protease renders the enzyme incapable of processing the Gag-Pol polyprotein precursor which leads to production of non-infectious immature HIV particles.
Ligand Summary
UNII: O3J8G9O825
PubChem: 392622
Guide to Pharmacology: 8804
ChEMBL: CHEMBL163
DrugCentral: 2391
LyCHI: N7SKXRKBPY6M
Target Activities
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10
1 – 6 of 6
CYP3A4
Cytochrome P450 3A4
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.8 | None, None:None:None | ||||
Ki | 7 | |||||
SLC47A1
Multidrug and toxin extrusion protein 1
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.1 | J. Med. Chem., (2013) 56:3:781 | ||||
IC50 | 7.1 | |||||
TBXAS1
Thromboxane-A synthase
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.12 | None, None:None:None | ||||
CYP2C9
Cytochrome P450 2C9
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.8 | None, None:None:None | ||||
CYP3A5
Cytochrome P450 3A5
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.92000008 | |||||
UGT1A1
UDP-glucuronosyltransferase 1-1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.76999998 | |||||