ritonavir
Ritonavir is a peptidomimetic inhibitor of the HIV-1 protease. Inhibition of HIV protease renders the enzyme incapable of processing the Gag-Pol polyprotein precursor which leads to production of non-infectious immature HIV particles. There was some evidence of in vitro activity against SARS-CoV-2, but no clinical trial data was found to support use in the treatment of COVID-19.
Ligand Summary
UNII: O3J8G9O825
PubChem: 392622
Guide to Pharmacology: 8804
ChEMBL: CHEMBL163
DrugCentral: 2391
LyCHI: N7SKXRKBPY6M
Target Activities
CYP3A4
Cytochrome P450 3A4
11 Activities
Items per page:
1 – 10 of 11
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7 | |||||
IC50 | 7.8 | None, None:None:None | ||||
IC50 | 7.52 | J. Med. Chem., (2003) 46:9:1716 | ||||
IC50 | 7.3 | Bioorg. Med. Chem. Lett., (2009) 19:18:5444 | ||||
Ki | 7 | Curr. Drug Metab., (2005) 6:1:413 | ||||
IC50 | 7 | Bioorg. Med. Chem. Lett., (2012) 22:9:3067 | ||||
IC50 | 6.96 | Bioorg. Med. Chem. Lett., (2014) 24:3:989 | ||||
IC50 | 6.89 | Bioorg Med Chem, (2020) 28:6:115349 | ||||
Ki | 6.77 | J. Med. Chem., (2012) 55:11:4896 | ||||
IC50 | 6.6 | Bioorg. Med. Chem. Lett., (1998) 8:24:3531 | ||||
CYP3A5
Cytochrome P450 3A5
2 Activities
SLCO1B1
Solute carrier organic anion transporter family member 1B1
2 Activities
SLC47A1
Multidrug and toxin extrusion protein 1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.1 | J. Med. Chem., (2013) 56:3:781 | ||||
IC50 | 7.1 | |||||
UGT1A1
UDP-glucuronosyltransferase 1-1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.77 | |||||
TBXAS1
Thromboxane-A synthase
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.12 | None, None:None:None | ||||
CYP2C9
Cytochrome P450 2C9
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.8 | None, None:None:None | ||||