risperidone
A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
Ligand Summary
UNII: L6UH7ZF8HC
PubChem: 5073
PubChem: 44402564
Guide to Pharmacology: 96
ChEMBL: CHEMBL85
ChEMBL: CHEMBL364512
DrugCentral: 2389
LyCHI: HBTADUAJZ6D9
Target Activities
Items per page:
10
1 – 10 of 24
HTR2C
5-hydroxytryptamine receptor 2C
19 Activities
Items per page:
1 – 10 of 19
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7 | MedChemComm, (2012) 3:5:580 | ||||
Ki | 7.04 | J. Med. Chem., (1999) 42:15:2774 | ||||
Ki | 7.2 | None, (2013) None:None:None | ||||
Ki | 7.2 | None, (2013) None:None:None | ||||
Ki | 7.2 | J. Med. Chem., (2004) 47:6:1303 | ||||
Ki | 7.38 | J. Med. Chem., (2000) 43:24:4678 | ||||
Ki | 7.38 | J. Med. Chem., (2002) 45:1:54 | ||||
Ki | 7.48 | Bioorg. Med. Chem. Lett., (2010) 20:18:5431 | ||||
Ki | 7.5 | J. Med. Chem., (2014) 57:22:9578 | ||||
IC50 | 7.82 | None, None:None:None | ||||
DRD2
D(2) dopamine receptor
19 Activities
Items per page:
1 – 10 of 19
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.7 | None, None:None:None | ||||
Ki | 8 | MedChemComm, (2012) 3:5:580 | ||||
Ki | 8.18 | None, None:None:None | ||||
Ki | 8.19 | J. Med. Chem., (2005) 48:6:1709 | ||||
Ki | 8.2 | J. Med. Chem., (2007) 50:21:5103 | ||||
Ki | 8.21 | MedChemComm, (2011) 2:12:1194 | ||||
Ki | 8.21 | Bioorg. Med. Chem. Lett., (2009) 19:21:6059 | ||||
Ki | 8.21 | Eur. J. Med. Chem., (2014) 71:None:237 | ||||
Ki | 8.23 | None, (2013) None:None:None | ||||
Ki | 8.23 | None, (2013) None:None:None | ||||
HTR2A
5-hydroxytryptamine receptor 2A
18 Activities
Items per page:
1 – 10 of 18
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9 | J. Med. Chem., (2007) 50:21:5103 | ||||
Ki | 9 | J. Med. Chem., (2014) 57:11:4543 | ||||
Ki | 9.09 | J. Med. Chem., (2005) 48:6:1709 | ||||
Ki | 9.3 | None, (2013) None:None:None | ||||
Ki | 9.3 | None, (2013) None:None:None | ||||
Ki | 9.3 | Bioorg. Med. Chem. Lett., (2007) 17:17:4873 | ||||
Ki | 9.3 | Bioorg. Med. Chem. Lett., (2004) 14:3:585 | ||||
Ki | 9.3 | MedChemComm, (2011) 2:12:1194 | ||||
Ki | 9.3 | Bioorg. Med. Chem. Lett., (2009) 19:21:6059 | ||||
Ki | 9.3 | Eur. J. Med. Chem., (2014) 71:None:237 | ||||
KCNH2
Potassium voltage-gated channel subfamily H member 2
14 Activities
Items per page:
1 – 10 of 14
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.38 | None, None:None:None | ||||
Ki | 5.46 | None, None:None:None | ||||
IC50 | 5.97 | Bioorg. Med. Chem. Lett., (2016) 26:13:3141 | ||||
Ki | 6.04 | J. Med. Chem., (2009) 52:1:151 | ||||
IC50 | 6.11 | MedChemComm, (2015) 6:5:831 | ||||
IC50 | 6.24 | J. Med. Chem., (2013) 56:11:4671 | ||||
IC50 | 6.58 | Bioorg. Med. Chem. Lett., (2004) 14:18:4771 | ||||
IC50 | 6.79 | Eur. J. Med. Chem., (2009) 44:5:1926 | ||||
IC50 | 6.82 | Bioorg. Med. Chem. Lett., (2005) 15:11:2886 | ||||
IC50 | 6.82 | Bioorg. Med. Chem., (2008) 16:11:6252 | ||||
DRD3
D(3) dopamine receptor
13 Activities
Items per page:
1 – 10 of 13
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7 | MedChemComm, (2012) 3:5:580 | ||||
Ki | 7.51 | J. Med. Chem., (1998) 41:27:5402 | ||||
IC50 | 7.62 | None, None:None:None | ||||
Ki | 7.79 | Bioorg. Med. Chem. Lett., (2009) 19:21:6059 | ||||
Ki | 7.8 | J. Med. Chem., (2005) 48:6:1709 | ||||
Ki | 7.85 | J. Med. Chem., (2001) 44:4:477 | ||||
Ki | 7.89 | J. Med. Chem., (2004) 47:6:1303 | ||||
Ki | 8 | J. Med. Chem., (2007) 50:21:5103 | ||||
Ki | 8.02 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
Ki | 8.1 | None, None:None:None | ||||
HRH1
Histamine H1 receptor
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7 | MedChemComm, (2012) 3:5:580 | ||||
Ki | 7.06 | J. Med. Chem., (2001) 44:4:477 | ||||
Ki | 7.48 | J. Med. Chem., (2005) 48:6:1709 | ||||
IC50 | 7.6 | None, None:None:None | ||||
Ki | 7.72 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
Ki | 8.54 | None, None:None:None | ||||
Ki | 8.59 | J. Med. Chem., (2004) 47:6:1303 | ||||
DRD4
D(4) dopamine receptor
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7 | MedChemComm, (2012) 3:5:580 | ||||
Ki | 7.8 | J. Med. Chem., (2004) 47:6:1303 | ||||
Ki | 7.8 | J. Med. Chem., (2001) 44:4:477 | ||||
Ki | 8 | J. Med. Chem., (2007) 50:21:5103 | ||||
Ki | 8.07 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
Ki | 8.15 | J. Med. Chem., (1995) 38:4:708 | ||||
Ki | 8.21 | J. Med. Chem., (1998) 41:27:5402 | ||||
ADRA1A
Alpha-1A adrenergic receptor
6 Activities
Items per page:
1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8 | MedChemComm, (2012) 3:5:580 | ||||
IC50 | 8 | Bioorg. Med. Chem. Lett., (2016) 26:13:3141 | ||||
Ki | 8.55 | Bioorg. Med. Chem. Lett., (2005) 15:3:657 | ||||
Ki | 8.64 | None, (2013) None:None:None | ||||
Ki | 8.64 | None, (2013) None:None:None | ||||
8.4 | ||||||
ADRA2C
Alpha-2C adrenergic receptor
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8 | MedChemComm, (2012) 3:5:580 | ||||
IC50 | 8.02 | None, None:None:None | ||||
Ki | 8.49 | J. Med. Chem., (2005) 48:6:1709 | ||||
Ki | 8.86 | None, None:None:None | ||||
ADRA1D
Alpha-1D adrenergic receptor
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8 | None, None:None:None | ||||
Ki | 8.31 | None, None:None:None | ||||
7.4 | ||||||