risperidone
A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
Ligand Summary
UNII: L6UH7ZF8HC
PubChem: 5073
Guide to Pharmacology: 96
ChEMBL: CHEMBL85
DrugCentral: 2389
LyCHI: HBTADUAJZ6D9
Target Activities
HTR2A
5-hydroxytryptamine receptor 2A
22 Activities
Items per page:
1 – 10 of 22
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
8.5 | ||||||
Ki | 10 | None, None:None:None | ||||
Ki | 9.82 | J. Med. Chem., (2014) 57:22:9578 | ||||
Ki | 9.8 | J. Med. Chem., (2004) 47:6:1303 | ||||
Ki | 9.54 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
IC50 | 9.46 | None, None:None:None | ||||
Ki | 9.43 | Eur J Med Chem, (2019) 180:None:673 | ||||
Ki | 9.41 | J. Med. Chem., (2001) 44:4:477 | ||||
Ki | 9.3 | Bioorg. Med. Chem. Lett., (2004) 14:3:585 | ||||
Ki | 9.3 | Bioorg. Med. Chem. Lett., (2007) 17:17:4873 | ||||
HTR2C
5-hydroxytryptamine receptor 2C
22 Activities
Items per page:
1 – 10 of 22
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.74 | Bioorg Med Chem, (2017) 25:17:4904 | ||||
IC50 | 8.74 | Eur J Med Chem, (2018) 145:None:74 | ||||
IC50 | 8.74 | Bioorg Med Chem Lett, (2020) 30:8:127027 | ||||
Ki | 8.19 | J. Med. Chem., (2001) 44:4:477 | ||||
IC50 | 8.15 | Bioorg. Med. Chem. Lett., (2016) 26:13:3141 | ||||
IC50 | 8.15 | Bioorg Med Chem Lett, (2018) 28:4:606 | ||||
Ki | 8.13 | Bioorg. Med. Chem. Lett., (2004) 14:3:585 | ||||
Ki | 8.13 | Bioorg. Med. Chem. Lett., (2007) 17:17:4873 | ||||
Ki | 8.13 | Bioorg. Med. Chem. Lett., (2009) 19:21:6059 | ||||
Ki | 8.12 | None, None:None:None | ||||
DRD2
D(2) dopamine receptor
20 Activities
Items per page:
1 – 10 of 20
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.36 | |||||
Ki | 9.36 | J. Med. Chem., (2001) 44:4:477 | ||||
Ki | 9.22 | Eur J Med Chem, (2018) 145:None:790 | ||||
Ki | 8.85 | J. Med. Chem., (1995) 38:4:708 | ||||
Ki | 8.66 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
Ki | 8.57 | J. Med. Chem., (2012) 55:22:9735 | ||||
Ki | 8.51 | Bioorg. Med. Chem. Lett., (2001) 11:17:2345 | ||||
Ki | 8.48 | J. Med. Chem., (2004) 47:6:1303 | ||||
Ki | 8.42 | J. Med. Chem., (2014) 57:22:9578 | ||||
Ki | 8.23 | None, (2013) None:None:None | ||||
KCNH2
Potassium voltage-gated channel subfamily H member 2
20 Activities
Items per page:
1 – 10 of 20
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.83 | J. Med. Chem., (2009) 52:14:4266 | ||||
IC50 | 6.83 | J. Med. Chem., (2009) 52:14:4266 | ||||
IC50 | 6.83 | Eur. J. Med. Chem., (2011) 46:2:618 | ||||
IC50 | 6.82 | Bioorg. Med. Chem. Lett., (2003) 13:16:2773 | ||||
IC50 | 6.82 | Bioorg. Med. Chem., (2008) 16:11:6252 | ||||
IC50 | 6.82 | Cardiovasc. Res., (2011) 91:None:53 | ||||
IC50 | 6.79 | J. Med. Chem., (2002) 45:18:3844 | ||||
IC50 | 6.79 | Bioorg. Med. Chem. Lett., (2005) 15:6:1737 | ||||
IC50 | 6.79 | Eur. J. Med. Chem., (2009) 44:5:1926 | ||||
IC50 | 6.78 | J Med Chem, (2018) 61:22:10017 | ||||
DRD3
D(3) dopamine receptor
13 Activities
Items per page:
1 – 10 of 13
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
7 | ||||||
Ki | 8.17 | J. Med. Chem., (2009) 52:1:151 | ||||
Ki | 8.17 | J. Med. Chem., (2014) 57:22:9578 | ||||
Ki | 8.1 | None, None:None:None | ||||
Ki | 8.02 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
Ki | 8 | J. Med. Chem., (2007) 50:21:5103 | ||||
Ki | 7.89 | J. Med. Chem., (2004) 47:6:1303 | ||||
Ki | 7.85 | J. Med. Chem., (2001) 44:4:477 | ||||
Ki | 7.8 | J. Med. Chem., (2005) 48:6:1709 | ||||
Ki | 7.79 | Bioorg. Med. Chem. Lett., (2009) 19:21:6059 | ||||
ADRA1A
Alpha-1A adrenergic receptor
9 Activities
Items per page:
1 – 9 of 9
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
8.4 | ||||||
Ki | 8.64 | None, (2013) None:None:None | ||||
Ki | 8.55 | Bioorg. Med. Chem. Lett., (2005) 15:3:657 | ||||
Ki | 8 | MedChemComm, (2012) 3:5:580 | ||||
IC50 | 8 | Bioorg. Med. Chem. Lett., (2016) 26:13:3141 | ||||
IC50 | 8 | Bioorg Med Chem Lett, (2018) 28:4:606 | ||||
IC50 | 7.96 | Bioorg Med Chem, (2017) 25:17:4904 | ||||
IC50 | 7.96 | Eur J Med Chem, (2018) 145:None:74 | ||||
IC50 | 7.96 | Bioorg Med Chem Lett, (2020) 30:8:127027 | ||||
HRH1
Histamine H1 receptor
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.59 | J. Med. Chem., (2004) 47:6:1303 | ||||
Ki | 8.54 | None, None:None:None | ||||
Ki | 7.72 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
IC50 | 7.6 | None, None:None:None | ||||
Ki | 7.48 | J. Med. Chem., (2005) 48:6:1709 | ||||
Ki | 7.06 | J. Med. Chem., (2001) 44:4:477 | ||||
Ki | 7 | MedChemComm, (2012) 3:5:580 | ||||
DRD4
D(4) dopamine receptor
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.21 | J. Med. Chem., (1998) 41:27:5402 | ||||
Ki | 8.15 | J. Med. Chem., (1995) 38:4:708 | ||||
Ki | 8.07 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
Ki | 8 | J. Med. Chem., (2007) 50:21:5103 | ||||
Ki | 7.8 | J. Med. Chem., (2004) 47:6:1303 | ||||
Ki | 7.8 | J. Med. Chem., (2001) 44:4:477 | ||||
Ki | 7 | MedChemComm, (2012) 3:5:580 | ||||
HTR7
5-hydroxytryptamine receptor 7
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.4 | Eur J Med Chem, (2018) 145:None:790 | ||||
Ki | 9 | J. Med. Chem., (2007) 50:21:5103 | ||||
Ki | 8.37 | J. Med. Chem., (2005) 48:6:1709 | ||||
Ki | 8 | MedChemComm, (2012) 3:5:580 | ||||
ADRA2C
Alpha-2C adrenergic receptor
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.86 | None, None:None:None | ||||
Ki | 8.49 | J. Med. Chem., (2005) 48:6:1709 | ||||
IC50 | 8.02 | None, None:None:None | ||||
Ki | 8 | MedChemComm, (2012) 3:5:580 | ||||
ADRA1D
Alpha-1D adrenergic receptor
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
7.4 | ||||||
Ki | 8.31 | None, None:None:None | ||||
IC50 | 8 | None, None:None:None | ||||
HTR2B
5-hydroxytryptamine receptor 2B
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.82 | None, None:None:None | ||||
Ki | 7.7 | J. Med. Chem., (2007) 50:21:5103 | ||||
IC50 | 7.64 | None, None:None:None | ||||
ADRA2A
Alpha-2A adrenergic receptor
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.44 | None, None:None:None | ||||
IC50 | 8.01 | None, None:None:None | ||||
Ki | 8 | J. Med. Chem., (2005) 48:6:1709 | ||||
HTR1A
5-hydroxytryptamine receptor 1A
2 Activities
ADRA1B
Alpha-1B adrenergic receptor
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
8 | ||||||
Ki | 8 | MedChemComm, (2012) 3:5:580 | ||||
ADRA2B
Alpha-2B adrenergic receptor
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.92 | None, None:None:None | ||||
IC50 | 7.58 | None, None:None:None | ||||
H1F0
Histone H1.0
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.85 | None, (2013) None:None:None | ||||
Ki | 7.85 | |||||
HTR1E
5-hydroxytryptamine receptor 1E
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
5.9 | ||||||
HTR1F
5-hydroxytryptamine receptor 1F
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
5.9 | ||||||
HTR6
5-hydroxytryptamine receptor 6
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
5.6 | ||||||
HTR1B
5-hydroxytryptamine receptor 1B
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8 | MedChemComm, (2012) 3:5:580 | ||||
SLC6A4
Sodium-dependent serotonin transporter
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6 | None, (2013) None:None:None | ||||
DRD1
D(1A) dopamine receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.68 | J. Med. Chem., (2001) 44:4:477 | ||||
GLRA1
Glycine receptor subunit alpha-1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 6.5 | J. Med. Chem., (2015) 58:7:2958 | ||||