raltitrexed
Ligand Summary
UNII: FCB9EGG971
PubChem: 104758
PubChem: 135400182
Guide to Pharmacology: 7403
ChEMBL: CHEMBL225071
DrugCentral: 2353
LyCHI: MF6Y2T6JTHDC
Target Activities
TYMS
Thymidylate synthase
17 Activities
Items per page:
1 – 10 of 17
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 6.38 | |||||
IC50 | 6.54 | |||||
IC50 | 6.58 | Eur. J. Med. Chem., (2013) 64:None:401 | ||||
IC50 | 6.54 | J. Med. Chem., (2010) 53:4:1563 | ||||
IC50 | 6.54 | Bioorg. Med. Chem., (2012) 20:14:4217 | ||||
IC50 | 6.42 | Bioorg. Med. Chem. Lett., (2005) 15:9:2225 | ||||
IC50 | 6.42 | J. Med. Chem., (2006) 49:3:1055 | ||||
IC50 | 6.42 | J. Med. Chem., (2004) 47:27:6730 | ||||
IC50 | 6.42 | J. Med. Chem., (2005) 48:23:7215 | ||||
IC50 | 6.42 | Bioorg. Med. Chem., (2010) 18:2:953 | ||||
FOLR2
Folate receptor beta
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.66 | J. Med. Chem., (2014) 57:19:8152 | ||||
IC50 | 7.66 | J Med Chem, (2018) 61:5:2027 | ||||
IC50 | 6.13 | J. Med. Chem., (2014) 57:19:8152 | ||||
IC50 | 6.13 | J Med Chem, (2018) 61:5:2027 | ||||
IC50 | 7.66 | |||||
FOLR1
Folate receptor alpha
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.82 | J. Med. Chem., (2014) 57:19:8152 | ||||
IC50 | 7.82 | J Med Chem, (2018) 61:5:2027 | ||||
IC50 | 7.82 | |||||
SLC46A1
Proton-coupled folate transporter
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7 | J. Med. Chem., (2014) 57:19:8152 | ||||
IC50 | 7 | J Med Chem, (2018) 61:5:2027 | ||||
IC50 | 7 | |||||
SLC19A1
Folate transporter 1
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.2 | J. Med. Chem., (2014) 57:19:8152 | ||||
IC50 | 8.2 | J Med Chem, (2018) 61:5:2027 | ||||
IC50 | 8.2 | |||||