Pharos : Ligand Details - raltitrexed

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

UNII: FCB9EGG971

PubChem: 104758

PubChem: 135400182

Guide to Pharmacology: 7403

ChEMBL: CHEMBL225071

DrugCentral: 2353

LyCHI: MF6Y2T6JTHDC

Target Activities

Explore Associated and Predicted Targets

TYMS

Tclin

Thymidylate synthase

17 Activities

Items per page:

1 – 10 of 17

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.38			1372358

IC50	6.54			22739090

IC50	6.58		Eur. J. Med. Chem., (2013) 64:None:401	23665106

IC50	6.54		J. Med. Chem., (2010) 53:4:1563	20092323

IC50	6.54		Bioorg. Med. Chem., (2012) 20:14:4217	22739090

IC50	6.42		Bioorg. Med. Chem. Lett., (2005) 15:9:2225	15837298

IC50	6.42		J. Med. Chem., (2006) 49:3:1055	16451071

IC50	6.42		J. Med. Chem., (2004) 47:27:6730	15615522

IC50	6.42		J. Med. Chem., (2005) 48:23:7215	16279780

IC50	6.42		Bioorg. Med. Chem., (2010) 18:2:953	20056546

FOLR2

Tchem

Folate receptor beta

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.66		J. Med. Chem., (2014) 57:19:8152	25234128

IC50	7.66		J Med Chem, (2018) 61:5:2027	29425443

IC50	6.13		J. Med. Chem., (2014) 57:19:8152	25234128

IC50	6.13		J Med Chem, (2018) 61:5:2027	29425443

IC50	7.66		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL225071

FOLR1

Tchem

Folate receptor alpha

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.82		J. Med. Chem., (2014) 57:19:8152	25234128

IC50	7.82		J Med Chem, (2018) 61:5:2027	29425443

IC50	7.82		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL225071

SLC46A1

Tchem

Proton-coupled folate transporter

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7		J. Med. Chem., (2014) 57:19:8152	25234128

IC50	7		J Med Chem, (2018) 61:5:2027	29425443

IC50	7		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL225071

SLC19A1

Tchem

Folate transporter 1

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.2		J. Med. Chem., (2014) 57:19:8152	25234128

IC50	8.2		J Med Chem, (2018) 61:5:2027	29425443

IC50	8.2		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL225071