Pharos : Ligand Details

Target Activities

ESR1

Tclin

Estrogen receptor

45 Activities

Items per page:

1 – 10 of 45

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
-	9.5		11150164

-	9.5		9048584

Ki	10.52	J. Med. Chem., (2005) 48:19:5989	16162002

Ki	9.8	None, None:None:None

IC50	9.74	Bioorg Med Chem, (2019) 27:10:1952	30940565

Ki	9.66	Bioorg. Med. Chem. Lett., (2001) 11:14:1939	11459665

IC50	9.52	Bioorg. Med. Chem. Lett., (2010) 20:17:5258	20659801

Ki	9.43	ACS Med. Chem. Lett., (2012) 3:3:207	22582136

Ki	9.42	ACS Med. Chem. Lett., (2012) 3:3:207	22582136

Ki	9.4	Bioorg. Med. Chem. Lett., (2003) 13:11:1907	12749895

ESR2

Tclin

Estrogen receptor beta

26 Activities

Items per page:

1 – 10 of 26

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8		11459665

IC50	8.8	Bioorg. Med. Chem. Lett., (2005) 15:11:2891	15911274

IC50	8.72	Bioorg. Med. Chem. Lett., (2005) 15:17:3912	15993065

Ki	8.56	ACS Med. Chem. Lett., (2012) 3:3:207	22582136

Ki	8.37	Bioorg. Med. Chem. Lett., (2003) 13:11:1907	12749895

Ki	8.37	Bioorg. Med. Chem., (2016) 24:4:759	26795112

Ki	8.35	J. Med. Chem., (2005) 48:19:5989	16162002

IC50	8.16	Bioorg. Med. Chem. Lett., (2010) 20:17:5258	20659801

IC50	8.09	J. Med. Chem., (2006) 49:11:3056	16722623

IC50	8.09	J. Med. Chem., (2009) 52:23:7544	19366247

AOX1

Tchem

Aldehyde oxidase

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	9.06	Drug Metab. Dispos., (2013) 41:1:24	22996261

Ki	9.05	J. Med. Chem., (2010) 53:24:8441	20853847

Ki	8.64	Drug Metab. Dispos., (2013) 41:1:24	22996261

IC50	8.52	J. Med. Chem., (2010) 53:24:8441	20853847

IC50	8.1	J Agric Food Chem, (2011) 59:9:4860	21476569

IC50	7.35	None, None:None:None

IC50	7.35

SIGMAR1

Tclin

Sigma non-opioid intracellular receptor 1

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.42	J. Med. Chem., (2005) 48:15:4754	16033255

Ki	6.54	None, None:None:None

IC50	6.17	None, None:None:None

SLC6A2

Tclin

Sodium-dependent noradrenaline transporter

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
IC50	6.55	None, None:None:None

Ki	6.55	None, None:None:None

GPER1

Tchem

G-protein coupled estrogen receptor 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
-	7			24379833

HTR2B

Tclin

5-hydroxytryptamine receptor 2B

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.16		J. Med. Chem., (2010) 53:21:7573	20958049

ACHE

Tclin

Acetylcholinesterase

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.4		None, None:None:None

EBP

Tchem

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	9		J. Med. Chem., (2005) 48:15:4754	16033255

C5

Tclin

Complement C5

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	6.15		Bioorg Med Chem, (2019) 27:19:115052	31447248