promethazine
A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
Ligand Summary
UNII: FF28EJQ494
PubChem: 4927
PubChem: 517306
Guide to Pharmacology: 7282
ChEMBL: CHEMBL643
ChEMBL: CHEMBL1200750
DrugCentral: 2286
LyCHI: H1LMQZFW5RCR
Target Activities
HRH1
Histamine H1 receptor
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.62 | |||||
Ki | 9.48 | None, None:None:None | ||||
IC50 | 8.54 | None, None:None:None | ||||
IC50 | 8.27 | J. Med. Chem., (2013) 56:22:8955 | ||||
Ki | 9.62 | ANTAGONIST | ||||
HTR2A
5-hydroxytryptamine receptor 2A
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.72 | None, None:None:None | ||||
IC50 | 7.64 | J. Med. Chem., (2013) 56:22:8955 | ||||
IC50 | 7.17 | None, None:None:None | ||||
CHRM3
Muscarinic acetylcholine receptor M3
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.38 | None, None:None:None | ||||
IC50 | 7.7 | None, None:None:None | ||||
CHRM4
Muscarinic acetylcholine receptor M4
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.98 | None, None:None:None | ||||
IC50 | 8.12 | None, None:None:None | ||||
HTR2B
5-hydroxytryptamine receptor 2B
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.37 | None, None:None:None | ||||
IC50 | 7.17 | None, None:None:None | ||||
CHRM1
Muscarinic acetylcholine receptor M1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.48 | None, None:None:None | ||||
IC50 | 7.85 | None, None:None:None | ||||
SIGMAR1
Sigma non-opioid intracellular receptor 1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.92 | None, None:None:None | ||||
IC50 | 6.54 | None, None:None:None | ||||
ADRA2B
Alpha-2B adrenergic receptor
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.62 | None, None:None:None | ||||
IC50 | 7.28 | None, None:None:None | ||||
HTR2C
5-hydroxytryptamine receptor 2C
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.19 | None, None:None:None | ||||
IC50 | 7.92 | None, None:None:None | ||||
CHRM5
Muscarinic acetylcholine receptor M5
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.48 | None, None:None:None | ||||
IC50 | 8.34 | None, None:None:None | ||||
GFER
FAD-linked sulfhydryl oxidase ALR
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
AC50 | 6.43 | None, None:None:None | ||||
AC50 | 6.44 | |||||
CHRM2
Muscarinic acetylcholine receptor M2
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.92 | None, None:None:None | ||||
IC50 | 7.46 | None, None:None:None | ||||
DRD2
D(2) dopamine receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7 | J. Med. Chem., (2013) 56:22:8955 | ||||
ADRA1D
Alpha-1D adrenergic receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.05 | None, None:None:None | ||||