progesterone
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Ligand Summary
UNII: 4G7DS2Q64Y
PubChem: 5994
Guide to Pharmacology: 2377
ChEMBL: CHEMBL103
DrugCentral: 2279
LyCHI: MD4GF5A4W2UC
Target Activities
PGR
Progesterone receptor
42 Activities
Items per page:
1 – 10 of 42
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.46 | |||||
EC50 | 8.82 | |||||
EC50 | 10 | J. Nat. Prod., (2009) 72:11:1944 | ||||
IC50 | 9.7 | ACS Med. Chem. Lett., (2011) 2:2:124 | ||||
EC50 | 9.3 | J. Med. Chem., (2008) 51:13:3696 | ||||
EC50 | 9.05 | Bioorg. Med. Chem. Lett., (2003) 13:7:1313 | ||||
EC50 | 9.05 | Bioorg. Med. Chem. Lett., (2008) 18:18:5015 | ||||
EC50 | 9.04 | Bioorg. Med. Chem. Lett., (2003) 13:7:1313 | ||||
EC50 | 9.04 | Bioorg. Med. Chem. Lett., (2002) 12:5:787 | ||||
EC50 | 8.82 | J. Med. Chem., (1998) 41:15:2779 | ||||
AR
Androgen receptor
13 Activities
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1 – 10 of 13
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.07 | J. Med. Chem., (1996) 39:9:1778 | ||||
Ki | 8.07 | Bioorg. Med. Chem. Lett., (1998) 8:23:3365 | ||||
Ki | 8.07 | J. Med. Chem., (2003) 46:19:4104 | ||||
Ki | 8.07 | J. Med. Chem., (1998) 41:22:4354 | ||||
Ki | 8.07 | J. Med. Chem., (1999) 42:8:1466 | ||||
Ki | 8.07 | J. Med. Chem., (1998) 41:3:291 | ||||
IC50 | 7.86 | Eur J Med Chem, (2019) 171:None:265 | ||||
Ki | 7.46 | Bioorg. Med. Chem., (2010) 18:12:4255 | ||||
IC50 | 7.43 | Bioorg. Med. Chem. Lett., (2003) 13:12:2071 | ||||
IC50 | 7.43 | J. Med. Chem., (1998) 41:3:291 | ||||
NR3C2
Mineralocorticoid receptor
7 Activities
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1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 11 | |||||
Kd | 9.41 | J. Med. Chem., (1996) 39:14:2860 | ||||
IC50 | 7.85 | J. Med. Chem., (1998) 41:22:4354 | ||||
IC50 | 7.85 | Bioorg. Med. Chem. Lett., (2003) 13:12:2071 | ||||
IC50 | 7.85 | J. Med. Chem., (1998) 41:3:291 | ||||
IC50 | 7.85 | J. Med. Chem., (2003) 46:19:4104 | ||||
IC50 | 7.52 | J. Med. Chem., (1996) 39:14:2860 | ||||
NR3C1
Glucocorticoid receptor
6 Activities
Items per page:
1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.52 | J. Med. Chem., (1996) 39:9:1778 | ||||
Ki | 7.52 | Bioorg. Med. Chem. Lett., (1998) 8:23:3365 | ||||
Ki | 7.52 | J. Med. Chem., (2003) 46:19:4104 | ||||
Ki | 7.52 | J. Med. Chem., (1998) 41:22:4354 | ||||
Ki | 7.52 | J. Med. Chem., (1999) 42:8:1466 | ||||
Ki | 7.52 | J. Med. Chem., (1998) 41:3:291 | ||||
CATSPER2
Cation channel sperm-associated protein 2
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.11 | |||||
EC50 | 8.11 | ACTIVATOR | ||||
CATSPER3
Cation channel sperm-associated protein 3
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.11 | |||||
EC50 | 8.11 | ACTIVATOR | ||||
CATSPER4
Cation channel sperm-associated protein 4
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.11 | |||||
EC50 | 8.11 | ACTIVATOR | ||||
TRPC5
Short transient receptor potential channel 5
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 5.3 | |||||
IC50 | 5.3 | BLOCKER | ||||
SERPINA6
Corticosteroid-binding globulin
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.38 | J. Med. Chem., (2004) 47:11:2732 | ||||
Ki | 7.38 | |||||
SHBG
Sex hormone-binding globulin
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 6.94 | J. Med. Chem., (2008) 51:7:2047 | ||||
Kd | 6.94 | |||||
P2RX3
P2X purinoceptor 3
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.8 | Eur J Med Chem, (2018) 151:None:462 | ||||
IC50 | 5.8 | |||||
SIGMAR1
Sigma non-opioid intracellular receptor 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.58 | J. Med. Chem., (2005) 48:15:4754 | ||||
CATSPER1
Cation channel sperm-associated protein 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.11 | ACTIVATOR | ||||