prednisolone
Ligand Summary
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
UNII: 9PHQ9Y1OLM
PubChem: 5755
Guide to Pharmacology: 2866
ChEMBL: CHEMBL131
DrugCentral: 2245
LyCHI: 62NHAD654ZAJ
Target Activities
NR3C1
Glucocorticoid receptor
93 Activities
Items per page:
1 – 10 of 93
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 7.8 | |||||
IC50 | 8.15 | |||||
IC50 | 9.28 | None, (2014) None:None:None | ||||
Ki | 8.94 | J. Med. Chem., (2014) 57:3:849 | ||||
Ki | 8.82 | Bioorg. Med. Chem. Lett., (2009) 19:8:2139 | ||||
Ki | 8.82 | J. Med. Chem., (2010) 53:23:8241 | ||||
Ki | 8.82 | J. Med. Chem., (2011) 54:20:7318 | ||||
IC50 | 8.68 | Bioorg. Med. Chem. Lett., (2004) 14:7:1721 | ||||
EC50 | 8.68 | J. Med. Chem., (2003) 46:6:1016 | ||||
IC50 | 8.68 | J. Med. Chem., (2001) 44:18:2879 | ||||
NR3C2
Mineralocorticoid receptor
10 Activities
Items per page:
1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.43 | |||||
IC50 | 7.96 | |||||
Ki | 9.54 | J. Med. Chem., (2014) 57:3:849 | ||||
EC50 | 8.7 | J. Med. Chem., (2010) 53:23:8241 | ||||
IC50 | 7.96 | J Med Chem, (2018) 61:5:1785 | ||||
IC50 | 7.75 | Bioorg Med Chem Lett, (2016) 26:23:5741 | ||||
Ki | 7.43 | J. Med. Chem., (2001) 44:18:2879 | ||||
IC50 | 7.36 | J. Med. Chem., (2010) 53:18:6681 | ||||
IC50 | 7.36 | Bioorg. Med. Chem. Lett., (2011) 21:22:6842 | ||||
IC50 | 7.36 | Bioorg. Med. Chem. Lett., (2014) 24:8:1934 | ||||
SERPINA6
Corticosteroid-binding globulin
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.51 | J. Med. Chem., (2004) 47:11:2732 | ||||
Ki | 7.51 | |||||
ADAM17
Disintegrin and metalloproteinase domain-containing protein 17
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.83 | None, (2014) None:None:None | ||||
IC50 | 7.83 | |||||
GLUL
Glutamine synthetase
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 7.5 | J. Med. Chem., (2004) 47:10:2441 | ||||
EC50 | 7.49 | |||||
IL6
Interleukin-6
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.38 | None, (2014) None:None:None | ||||