ponesimod
Ligand Summary
Ponesimod is a sphingosine 1-phosphate (S1P) receptor 1 modulator that binds with high affinity to S1P receptor 1. Ponesimod blocks the capacity of lymphocytes to egress from lymph nodes, reducing the number of lymphocytes in peripheral blood. The mechanism by which ponesimod exerts therapeutic effects in multiple sclerosis is unknown, but may involve reduction of lymphocyte migration into the central nervous system
UNII: 5G7AKV2MKP
PubChem: 11363176
Guide to Pharmacology: 9320
ChEMBL: CHEMBL1096146
DrugCentral: 5446
LyCHI: 4DVYJN2JZLF5
Target Activities
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | ||||||
IC50 | ||||||
IC50 | ||||||
IC50 | ||||||
EC50 | AGONIST | |||||