Pharos : Ligand Details

Target Activities

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1 – 10 of 13

ABL1

Tclin

Tyrosine-protein kinase ABL1

15 Activities

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1 – 10 of 15

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.07	J. Med. Chem., (2010) 53:12:4701	20513156

IC50	8.07	Bioorg. Med. Chem. Lett., (2011) 21:12:3743	21561767

IC50	8.54	J. Med. Chem., (2013) 56:14:5757	23773153

IC50	8.85	J. Med. Chem., (2013) 56:3:879	23301703

IC50	8.86	J. Med. Chem., (2013) 56:3:879	23301703

IC50	8.97	J. Med. Chem., (2013) 56:3:879	23301703

IC50	9	None, (2016) None:None:None

IC50	9.3	J. Med. Chem., (2013) 56:3:879	23301703

IC50	9.37	J. Med. Chem., (2013) 56:3:879	23301703

IC50	9.39	J. Med. Chem., (2013) 56:3:879	23301703

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.59	J. Med. Chem., (2015) 58:9:3672	25625428

IC50	9.05	Bioorg Med Chem Lett, (2016) 26:23:5679	27815117

IC50	8.19999981		23811235

KDR

Tclin

Vascular endothelial growth factor receptor 2

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.37	ACS Med. Chem. Lett., (2014) 5:6:673	24944742

IC50	8.77	Bioorg. Med. Chem. Lett., (2014) 24:24:5639	25467150

KIT

Tclin

Mast/stem cell growth factor receptor Kit

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.31	J. Med. Chem., (2013) 56:14:5757	23773153

IC50	8.77	J. Med. Chem., (2013) 56:14:5757	23773153

CDK19

Tchem

Cyclin-dependent kinase 19

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.92000008			26502155

Kd	7.92	INHIBITOR	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5890

CDK8

Tchem

Cyclin-dependent kinase 8

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.17000008			26502155

Kd	8.17	INHIBITOR	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5890

FGFR1

Tclin

Fibroblast growth factor receptor 1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9.15		Bioorg. Med. Chem. Lett., (2014) 24:24:5639	25467150

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9.52		MedChemComm, (2012) 3:1:22

SRC

Tclin

Proto-oncogene tyrosine-protein kinase Src

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.52		J. Med. Chem., (2015) 58:9:3957	25835317

RIPK1

Tchem

Receptor-interacting serine/threonine-protein kinase 1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.92000008			25801024