pethidine
Ligand Summary
A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
UNII: 9E338QE28F
PubChem: 4058
Guide to Pharmacology: 7221
ChEMBL: CHEMBL607
DrugCentral: 1690
LyCHI: SZVHZB4KFT4M
Target Activities
OPRM1
Mu-type opioid receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.5 | |||||
Ki | 6.04 | AGONIST | ||||
OPRD1
Delta-type opioid receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 5 | |||||
OPRK1
Kappa-type opioid receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 5.63 | |||||
KCNH2
Potassium voltage-gated channel subfamily H member 2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.49 | Bioorg. Med. Chem. Lett., (2005) 15:11:2886 | ||||