pentoxifylline
A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.
Ligand Summary
UNII: SD6QCT3TSU
PubChem: 4740
Guide to Pharmacology: 7095
ChEMBL: CHEMBL628
DrugCentral: 2099
LyCHI: QN7ZYW5JAXF3
Target Activities
ADORA2B
Adenosine receptor A2b
2 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 5.29 | |||||
Ki | 5.29 | ANTAGONIST | ||||
PDE4B
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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INHIBITOR | ||||||
PDE5A
cGMP-specific 3',5'-cyclic phosphodiesterase
1 Activities
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INHIBITOR | ||||||