pentamidine
Ligand Summary
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
UNII: 673LC5J4LQ
PubChem: 4735
ChEMBL: CHEMBL55
DrugCentral: 2090
LyCHI: ZWTYU7KAJWPZ
Target Activities
AOC1
Amiloride-sensitive amine oxidase [copper-containing]
2 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.54 | Bioorg. Med. Chem., (2014) 22:7:1983 | ||||
Ki | 6.54 | |||||
S100B
Protein S100-B
2 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 6 | J. Med. Chem., (2004) 47:21:5085 | ||||
Kd | 6 | |||||
PTP4A1
Protein tyrosine phosphatase type IVA 1
2 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.52 | Bioorg Med Chem Lett, (2019) 29:16:2008 | ||||
IC50 | 6.52 | |||||
SLC47A1
Multidrug and toxin extrusion protein 1
2 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.39 | J. Med. Chem., (2013) 56:3:781 | ||||
IC50 | 6.39 | |||||
PTP4A2
Protein tyrosine phosphatase type IVA 2
2 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.52 | Bioorg Med Chem Lett, (2019) 29:16:2008 | ||||
IC50 | 6.52 | |||||
MAOA
Amine oxidase [flavin-containing] A
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.1 | None, None:None:None | ||||
KCNH2
Potassium voltage-gated channel subfamily H member 2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5 | J Med Chem, (2019) 62:8:3989 | ||||
PTP4A3
Protein tyrosine phosphatase type IVA 3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.52 | Bioorg Med Chem Lett, (2019) 29:16:2008 | ||||