pemigatinib
Pemigatinib inhibited FGFR1-3 phosphorylation and signaling and decreased cell viability in cancer cell lines with activating FGFR amplifications and fusions that resulted in constitutive activation of FGFR signaling
Ligand Summary
UNII: Y6BX7BL23K
PubChem: 86705695
Guide to Pharmacology: 9767
ChEMBL: CHEMBL4297522
DrugCentral: 5390
LyCHI: QYT59LXCG4YV
Target Activities
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10
1 – 3 of 3
FGFR2
Fibroblast growth factor receptor 2
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7 | |||||
IC50 | 9.3 | INHIBITOR | ||||
FGFR3
Fibroblast growth factor receptor 3
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7 | |||||
IC50 | 9 | INHIBITOR | ||||
FGFR1
Fibroblast growth factor receptor 1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.4 | INHIBITOR | ||||