Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

SLC6A4

Tclin

Sodium-dependent serotonin transporter

18 Activities

Items per page:

1 – 10 of 18

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	9.6		9537821

Kd	10.1		27049939

Ki	10.4	J. Med. Chem., (2005) 48:19:6023	16162005

Ki	10.37	None, None:None:None

Ki	10.11	Bioorg. Med. Chem. Lett., (1995) 5:19:2287

IC50	10.1	None, None:None:None

Ki	10.05	Bioorg. Med. Chem., (2007) 15:24:7581	17900912

Ki	9.96	Bioorg Med Chem, (2017) 25:1:293	27865645

Kd	9.89	Bioorg. Med. Chem. Lett., (1998) 8:5:487	9871604

IC50	9.7	Bioorg. Med. Chem., (2013) 21:8:2217	23477943

SLC6A2

Tclin

Sodium-dependent noradrenaline transporter

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.4	Bioorg. Med. Chem. Lett., (1998) 8:5:487	9871604

IC50	7.07	None, None:None:None

Ki	7.07	None, None:None:None

Ki	7.05	J. Med. Chem., (2005) 48:19:6023	16162005

IC50	7	Bioorg. Med. Chem. Lett., (2008) 18:18:4929	18771916

SLC6A3

Tclin

Sodium-dependent dopamine transporter

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.4	J. Med. Chem., (2005) 48:19:6023	16162005

Kd	6.31	Bioorg. Med. Chem. Lett., (1998) 8:5:487	9871604

Ki	6.27	None, None:None:None

IC50	6.17	None, None:None:None

P2RX4

Tchem

P2X purinoceptor 4

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	5.73	J. Med. Chem., (2012) 55:22:9576	23075067

IC50	5.73	J Med Chem, (2019) 62:24:11194	31746599

IC50	5.33	Bioorg. Med. Chem., (2014) 22:3:1077	24411477

IC50	5.33	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200609

MPO

Tchem

Myeloperoxidase

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.7	J Med Chem, (2017) 60:15:6563	28671460

IC50	7.7	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200609

CYP2D6

Tclin

Cytochrome P450 2D6

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.02	Drug Metab. Dispos., (2012) 40:5:943	22328583

IC50	6	None, None:None:None

CHRM3

Tclin

Muscarinic acetylcholine receptor M3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.42		None, None:None:None

CHRM4

Tclin

Muscarinic acetylcholine receptor M4

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.47		None, None:None:None

CHRM1

Tclin

Muscarinic acetylcholine receptor M1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.46		None, None:None:None

KCNH2

Tclin

Potassium voltage-gated channel subfamily H member 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	5.07		None, None:None:None

CHRM5

Tclin

Muscarinic acetylcholine receptor M5

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.05		None, None:None:None