paroxetine
A serotonin uptake inhibitor that is effective in the treatment of depression.
Ligand Summary
UNII: 41VRH5220H
PubChem: 9845306
PubChem: 43815
PubChem: 68492682
Guide to Pharmacology: 4790
ChEMBL: CHEMBL1200609
ChEMBL: CHEMBL490
ChEMBL: CHEMBL1708
DrugCentral: 2068
LyCHI: TPG4Q6ZJ88Z3
Target Activities
SLC6A4
Sodium-dependent serotonin transporter
18 Activities
Items per page:
1 – 10 of 18
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 9.6 | |||||
Kd | 10.1 | |||||
Ki | 10.4 | J. Med. Chem., (2005) 48:19:6023 | ||||
Ki | 10.37 | None, None:None:None | ||||
Ki | 10.11 | Bioorg. Med. Chem. Lett., (1995) 5:19:2287 | ||||
IC50 | 10.1 | None, None:None:None | ||||
Ki | 10.05 | Bioorg. Med. Chem., (2007) 15:24:7581 | ||||
Ki | 9.96 | Bioorg Med Chem, (2017) 25:1:293 | ||||
Kd | 9.89 | Bioorg. Med. Chem. Lett., (1998) 8:5:487 | ||||
IC50 | 9.7 | Bioorg. Med. Chem., (2013) 21:8:2217 | ||||
SLC6A2
Sodium-dependent noradrenaline transporter
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.4 | Bioorg. Med. Chem. Lett., (1998) 8:5:487 | ||||
IC50 | 7.07 | None, None:None:None | ||||
Ki | 7.07 | None, None:None:None | ||||
Ki | 7.05 | J. Med. Chem., (2005) 48:19:6023 | ||||
IC50 | 7 | Bioorg. Med. Chem. Lett., (2008) 18:18:4929 | ||||
SLC6A3
Sodium-dependent dopamine transporter
4 Activities
P2RX4
P2X purinoceptor 4
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 5.73 | J. Med. Chem., (2012) 55:22:9576 | ||||
IC50 | 5.73 | J Med Chem, (2019) 62:24:11194 | ||||
IC50 | 5.33 | Bioorg. Med. Chem., (2014) 22:3:1077 | ||||
IC50 | 5.33 | |||||
MPO
Myeloperoxidase
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.7 | J Med Chem, (2017) 60:15:6563 | ||||
IC50 | 7.7 | |||||
CYP2D6
Cytochrome P450 2D6
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.02 | Drug Metab. Dispos., (2012) 40:5:943 | ||||
IC50 | 6 | None, None:None:None | ||||
CHRM3
Muscarinic acetylcholine receptor M3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.42 | None, None:None:None | ||||
CHRM4
Muscarinic acetylcholine receptor M4
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.47 | None, None:None:None | ||||
CHRM1
Muscarinic acetylcholine receptor M1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.46 | None, None:None:None | ||||
KCNH2
Potassium voltage-gated channel subfamily H member 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 5.07 | None, None:None:None | ||||
CHRM5
Muscarinic acetylcholine receptor M5
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.05 | None, None:None:None | ||||