paclitaxel
Ligand Summary
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
UNII: P88XT4IS4D
PubChem: 36314
Guide to Pharmacology: 2770
ChEMBL: CHEMBL428647
DrugCentral: 2044
LyCHI: F6F6DK8FGGAH
Target Activities
TUBB3
Tubulin beta-3 chain
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.11 | J. Med. Chem., (2013) 56:17:6829 | ||||
IC50 | 8.04 | Bioorg. Med. Chem., (2013) 21:4:891 | ||||
EC50 | 8.05 | INHIBITOR | ||||
TUBB
Tubulin beta chain
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.05 | |||||
EC50 | 8.05 | INHIBITOR | ||||
SLCO1B1
Solute carrier organic anion transporter family member 1B1
2 Activities
NR1I2
Nuclear receptor subfamily 1 group I member 2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
5.3 | ||||||
SLCO1B3
Solute carrier organic anion transporter family member 1B3
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.58 | Eur. J. Med. Chem., (2015) 92:None:723 | ||||
TUBB1
Tubulin beta-1 chain
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.05 | INHIBITOR | ||||
TUBB2A
Tubulin beta-2A chain
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.05 | INHIBITOR | ||||
TUBB2B
Tubulin beta-2B chain
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.05 | INHIBITOR | ||||
TUBB4A
Tubulin beta-4A chain
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.05 | INHIBITOR | ||||
TUBB4B
Tubulin beta-4B chain
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.05 | INHIBITOR | ||||
TUBB6
Tubulin beta-6 chain
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.05 | INHIBITOR | ||||
TUBB8
Tubulin beta-8 chain
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.05 | INHIBITOR | ||||