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osimertinib

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Osimertinib is a kinase inhibitor of the epidermal growth factor receptor (EGFR), which binds irreversibly to certain mutant forms of EGFR (T790M, L858R, and exon 19 deletion) at approximately 9-fold lower concentrations than wild-type. In cultured cells and animal tumor implantation models, osimertinib exhibited anti-tumor activity against NSCLC lines harboring EGFR-mutations (T790M/L858R, L858R, T790M/exon 19 deletion, and exon 19 deletion) and, to a lesser extent, wild-type EGFR amplifications.
Synonyms & Links
Guide to Pharmacology: 7719
DrugCentral: 5062
LyCHI:  5WWKT2A98AXL


Target Activities