Pharos : Ligand Details - osilodrostat

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Osilodrostat is a cortisol synthesis inhibitor. It inhibits 11beta-hydroxylase (CYP11B1), the enzyme responsible for the final step of cortisol biosynthesis in the adrenal gland

Ligand Summary

Ligand Structure

chemical structure image

Synonyms & Links

UNII: 5YL4IQ1078

PubChem: 44139752

Guide to Pharmacology: 8310

ChEMBL: CHEMBL3099695

DrugCentral: 5384

LyCHI: STDN8F8KBURH

Target Activities

CYP11B2

Tchem

Cytochrome P450 11B2, mitochondrial

11 Activities

Items per page:

1 – 10 of 11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.05		ACS Med. Chem. Lett., (2013) 4:12:1203	24900631

IC50	8.52		J. Med. Chem., (2015) 58:20:8054	26403853

IC50	9.15		ACS Med. Chem. Lett., (2013) 4:12:1203	24900631

IC50	9.15		J. Med. Chem., (2015) 58:23:9382	26540564

IC50	9.7		J. Med. Chem., (2014) 57:12:5011	24422519

IC50	9.7		J. Med. Chem., (2014) 57:12:5179	24899257

IC50	9.7		J. Med. Chem., (2014) 57:12:5179	24899257

IC50	9.7		Eur. J. Med. Chem., (2015) 90:None:788	25528333

IC50	9.7		J. Med. Chem., (2015) 58:5:2530	25711516

IC50	9.69999981			24899257

CYP11B1

Tclin

Cytochrome P450 11B1, mitochondrial

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.54		J. Med. Chem., (2014) 57:12:5011	24422519

IC50	8.54		J. Med. Chem., (2014) 57:12:5179	24899257

IC50	8.54		Eur. J. Med. Chem., (2015) 90:None:788	25528333

IC50	8.54		J. Med. Chem., (2015) 58:5:2530	25711516

IC50	8.6		ACS Med. Chem. Lett., (2013) 4:12:1203	24900631

IC50	8.6		J. Med. Chem., (2015) 58:23:9382	26540564

IC50	8.53999996			24899257

IC50	8.6	INHIBITOR	https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/212801s000lbl.pdf

CYP19A1

Tclin

Aromatase

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.07		J. Med. Chem., (2014) 57:12:5011	24422519