osilodrostat
Osilodrostat is a cortisol synthesis inhibitor. It inhibits 11beta-hydroxylase (CYP11B1), the enzyme responsible for the final step of cortisol biosynthesis in the adrenal gland
Ligand Summary
UNII: 5YL4IQ1078
PubChem: 71009737
PubChem: 44139752
Guide to Pharmacology: 8310
ChEMBL: CHEMBL3707393
ChEMBL: CHEMBL3099695
DrugCentral: 5384
LyCHI: STDN8F8KBURH
Target Activities
CYP11B2
Cytochrome P450 11B2, mitochondrial
13 Activities
Items per page:
1 – 10 of 13
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 9.7 | |||||
IC50 | 9.7 | J. Med. Chem., (2014) 57:12:5179 | ||||
IC50 | 9.7 | J. Med. Chem., (2014) 57:12:5179 | ||||
IC50 | 9.7 | J. Med. Chem., (2014) 57:12:5011 | ||||
IC50 | 9.7 | Eur. J. Med. Chem., (2015) 90:None:788 | ||||
IC50 | 9.7 | J. Med. Chem., (2015) 58:5:2530 | ||||
IC50 | 9.7 | J Med Chem, (2017) 60:12:5086 | ||||
IC50 | 9.15 | ACS Med. Chem. Lett., (2013) 4:12:1203 | ||||
IC50 | 9.15 | J. Med. Chem., (2015) 58:23:9382 | ||||
IC50 | 8.92 | J Med Chem, (2018) 61:13:5594 | ||||
CYP11B1
Cytochrome P450 11B1, mitochondrial
10 Activities
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1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.54 | |||||
IC50 | 8.6 | ACS Med. Chem. Lett., (2013) 4:12:1203 | ||||
IC50 | 8.6 | J. Med. Chem., (2015) 58:23:9382 | ||||
IC50 | 8.54 | J. Med. Chem., (2014) 57:12:5179 | ||||
IC50 | 8.54 | J. Med. Chem., (2014) 57:12:5011 | ||||
IC50 | 8.54 | Eur. J. Med. Chem., (2015) 90:None:788 | ||||
IC50 | 8.54 | J. Med. Chem., (2015) 58:5:2530 | ||||
IC50 | 8.52 | J Med Chem, (2017) 60:12:5086 | ||||
IC50 | 7.66 | J Med Chem, (2018) 61:13:5594 | ||||
IC50 | 8.6 | INHIBITOR | ||||
CYP19A1
Aromatase
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.07 | J. Med. Chem., (2014) 57:12:5011 | ||||