orlistat
A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity.
Ligand Summary
UNII: 95M8R751W8
PubChem: 3034010
Guide to Pharmacology: 5277
ChEMBL: CHEMBL175247
DrugCentral: 1996
LyCHI: F17BATCFGD4H
Target Activities
ABHD12
Monoacylglycerol lipase ABHD12
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.72 | Bioorg. Med. Chem. Lett., (2015) 25:7:1436 | ||||
IC50 | 6.72 | Bioorg. Med. Chem. Lett., (2015) 25:7:1436 | ||||
IC50 | 6.72 | Bioorg. Med. Chem., (2015) 23:19:6335 | ||||
IC50 | 6.72 | Bioorg. Med. Chem., (2015) 23:19:6335 | ||||
IC50 | 7.1 | Bioorg. Med. Chem. Lett., (2008) 18:22:5838 | ||||
IC50 | 7.0999999 | |||||
IC50 | 7.1 | |||||
ABHD6
Monoacylglycerol lipase ABHD6
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.32 | Bioorg. Med. Chem. Lett., (2015) 25:7:1436 | ||||
IC50 | 7.32 | Bioorg. Med. Chem. Lett., (2015) 25:7:1436 | ||||
IC50 | 7.43 | Bioorg. Med. Chem., (2015) 23:19:6335 | ||||
IC50 | 7.7 | Bioorg. Med. Chem., (2015) 23:19:6335 | ||||
IC50 | 7.85 | Bioorg. Med. Chem., (2015) 23:19:6335 | ||||
IC50 | 7.88 | Bioorg. Med. Chem., (2015) 23:19:6335 | ||||
IC50 | 7.32000017 | |||||
DAGLA
Sn1-specific diacylglycerol lipase alpha
6 Activities
Items per page:
1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6 | J. Med. Chem., (2008) 51:21:6970 | ||||
IC50 | 7.22 | Bioorg. Med. Chem. Lett., (2008) 18:22:5838 | ||||
IC50 | 8 | Bioorg. Med. Chem. Lett., (2012) 22:14:4585 | ||||
IC50 | 9 | Bioorg. Med. Chem., (2016) 24:7:1455 | ||||
IC50 | 7.19999981 | |||||
IC50 | 8 | |||||
DAGLB
Sn1-specific diacylglycerol lipase beta
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.38 | Bioorg. Med. Chem., (2016) 24:7:1455 | ||||
IC50 | 7.22 | Bioorg. Med. Chem. Lett., (2008) 18:22:5838 | ||||
IC50 | 7 | |||||
IC50 | 7.22 | |||||
PLA2G7
Platelet-activating factor acetylhydrolase
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.3 | Bioorg. Med. Chem. Lett., (2008) 18:22:5838 | ||||
IC50 | 7.3 | |||||
ABHD16A
Protein ABHD16A
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.52 | Bioorg. Med. Chem. Lett., (2008) 18:22:5838 | ||||
IC50 | 7.52 | |||||
PNLIP
Pancreatic triacylglycerol lipase
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.89999962 | |||||
IC50 | 8.9 | INHIBITOR | ||||
LIPF
Gastric triacylglycerol lipase
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
INHIBITOR | ||||||