Pharos : Ligand Details - omapatrilat

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

PubChem: 656629

ChEMBL: CHEMBL289556

DrugCentral: 1989

LyCHI: 6HVZN4NT6JSF

Target Activities

ACE

Tclin

Angiotensin-converting enzyme

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	10.82		J Med Chem, (2018) 61:22:10141	30372620

Ki	10.8		J Med Chem, (2018) 61:22:10141	30372620

IC50	10		ACS Med Chem Lett, (2019) 10:1:86	30655952

IC50	9		J Med Chem, (2018) 61:22:10141	30372620

IC50	8.7		J Med Chem, (2018) 61:22:10141	30372620

Ki	8.22		J. Med. Chem., (2010) 53:1:208	19899765

APP

Tchem

Amyloid-beta A4 protein

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.7		ACS Med Chem Lett, (2019) 10:1:86	30655952

IC50	6.7		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL289556

MME

Tclin

Neprilysin

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9.7		ACS Med Chem Lett, (2019) 10:1:86	30655952

Ki	8.05		J. Med. Chem., (2010) 53:1:208	19899765