Pharos : Ligand Details - olmesartan medoxomil

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Description

Olmesartan blocks the vasoconstrictor effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in vascular smooth muscle.

Synonyms & Links

UNII: 6M97XTV3HD

PubChem: 130881

Guide to Pharmacology: 591

ChEMBL: CHEMBL1200692

DrugCentral: 1985

LyCHI: KUVPWHRXXN1N

Target Activities

Explore Associated and Predicted Targets

AGTR1

Tclin

Type-1 angiotensin II receptor

2 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
-	8.1			11451212

IC50	8.1	ANTAGONIST	http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=591

SLCO1B1

Tchem

Solute carrier organic anion transporter family member 1B1

2 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.27		Mol. Pharmacol., (2013) 83:6:1257	23571415

IC50	6.01		Mol. Pharmacol., (2013) 83:6:1257	23571415

SLCO1B3

Tchem

Solute carrier organic anion transporter family member 1B3

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.12		Mol. Pharmacol., (2013) 83:6:1257	23571415

IC50	6.01		Mol. Pharmacol., (2013) 83:6:1257	23571415