octreotide
Ligand Summary
A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat hormone-secreting tumors; DIABETES MELLITUS; HYPOTENSION, ORTHOSTATIC; HYPERINSULINISM; hypergastrinemia; and small bowel fistula.
UNII: RWM8CCW8GP
PubChem: 448601
ChEMBL: CHEMBL1680
DrugCentral: 1980
LyCHI: 8GQHYX4RF41G
Target Activities
SSTR2
Somatostatin receptor type 2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 10.7 | AGONIST | ||||
SSTR3
Somatostatin receptor type 3
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.3 | AGONIST | ||||
SSTR5
Somatostatin receptor type 5
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.52 | AGONIST | ||||
SSTR4
Somatostatin receptor type 4
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.4 | AGONIST | ||||
SSTR1
Somatostatin receptor type 1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.65 | AGONIST | ||||