obeticholic acid
obeticholic acid is an agonist for FXR, a nuclear receptor expressed in the liver and intestine
Ligand Summary
UNII: 0462Z4S4OZ
PubChem: 447715
Guide to Pharmacology: 3435
ChEMBL: CHEMBL566315
DrugCentral: 5155
LyCHI: LAT554DATTNC
Target Activities
NR1H4
Bile acid receptor
14 Activities
Items per page:
1 – 10 of 14
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 7 | |||||
EC50 | 8 | J Med Chem, (2017) 60:24:9960 | ||||
EC50 | 7.38 | J Med Chem, (2017) 60:24:9960 | ||||
EC50 | 7.07 | J. Med. Chem., (2014) 57:19:8035 | ||||
EC50 | 7.07 | J Med Chem, (2020) 63:10:5031 | ||||
EC50 | 7.05 | J. Med. Chem., (2004) 47:18:4559 | ||||
EC50 | 7.01 | J. Med. Chem., (2006) 49:14:4208 | ||||
EC50 | 7 | Bioorg. Med. Chem. Lett., (2003) 13:11:1865 | ||||
EC50 | 7 | J. Med. Chem., (2002) 45:17:3569 | ||||
EC50 | 7 | J. Med. Chem., (2005) 48:17:5383 | ||||
GPBAR1
G-protein coupled bile acid receptor 1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 7 | ACS Med. Chem. Lett., (2013) 4:12:1158 | ||||
EC50 | 7 | |||||