norepinephrine
Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic.
Ligand Summary
UNII: X4W3ENH1CV
PubChem: 11957447
PubChem: 439260
Guide to Pharmacology: 505
ChEMBL: CHEMBL1356607
ChEMBL: CHEMBL1437
DrugCentral: 1960
LyCHI: NMF7HVW8US3U
Target Activities
ADRB3
Beta-3 adrenergic receptor
4 Activities
ADRA1D
Alpha-1D adrenergic receptor
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 6.3 | |||||
- | 7.4 | |||||
Ki | 7.4 | AGONIST | ||||
ADRA1A
Alpha-1A adrenergic receptor
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.04 | J. Med. Chem., (2015) 58:15:6048 | ||||
EC50 | 8.04 | J Med Chem, (2017) 60:8:3252 | ||||
Ki | 5.82 | AGONIST | ||||
ADRA2B
Alpha-2B adrenergic receptor
3 Activities
ADRA1B
Alpha-1B adrenergic receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
6.2 | ||||||
Ki | 4.69 | AGONIST | ||||
ADRA2A
Alpha-2A adrenergic receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.18 | J. Med. Chem., (1996) 39:6:1193 | ||||
Ki | 7.18 | AGONIST | ||||
ADRA2C
Alpha-2C adrenergic receptor
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.2 | J. Med. Chem., (1996) 39:6:1193 | ||||
Ki | 7.2 | AGONIST | ||||
ADRB2
Beta-2 adrenergic receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 5.4 | AGONIST | ||||
ADRB1
Beta-1 adrenergic receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6 | AGONIST | ||||