nitric oxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP. It has been shown to have in vitro activity against severe acute res-piratory syndrome corona-virus (SARS-CoV-1) but evidence supporting the use of inhaled nitric oxide in COVID-19 patients is currently limited.
Ligand Summary
Target Activities
GUCY1B2
Guanylate cyclase soluble subunit beta-2
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GUCY1A2
Guanylate cyclase soluble subunit alpha-2
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GUCY1A1
Guanylate cyclase soluble subunit alpha-1
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GUCY1B1
Guanylate cyclase soluble subunit beta-1
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