nitrendipine
Ligand Summary
A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
UNII: 9B627AW319
PubChem: 157702
PubChem: 4507
Guide to Pharmacology: 2334
ChEMBL: CHEMBL251230
ChEMBL: CHEMBL475534
DrugCentral: 1947
LyCHI: WW68FQ371HYW
Target Activities
KCNH2
Potassium voltage-gated channel subfamily H member 2
5 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5 | Bioorg. Med. Chem. Lett., (2003) 13:16:2773 | ||||
IC50 | 5 | Bioorg. Med. Chem. Lett., (2005) 15:11:2886 | ||||
IC50 | 5 | Bioorg. Med. Chem., (2008) 16:11:6252 | ||||
IC50 | 5 | Eur. J. Med. Chem., (2011) 46:2:618 | ||||
IC50 | 5 | Cardiovasc. Res., (2011) 91:None:53 | ||||
KCNN4
Intermediate conductance calcium-activated potassium channel protein 4
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 7.6 | |||||
- | 6.1 | |||||
IC50 | 7.6 | BLOCKER | ||||
CACNA1C
Voltage-dependent L-type calcium channel subunit alpha-1C
3 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.6 | J. Med. Chem., (1987) 30:4:690 | ||||
Kd | 9.59 | J. Med. Chem., (1990) 33:5:1510 | ||||
Ki | 9.6 | BLOCKER | ||||
CACNA1D
Voltage-dependent L-type calcium channel subunit alpha-1D
2 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.4 | |||||
IC50 | 8.4 | GATING INHIBITOR | ||||
CACNA1F
Voltage-dependent L-type calcium channel subunit alpha-1F
2 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6 | |||||
IC50 | 6 | GATING INHIBITOR | ||||
CACNA1S
Voltage-dependent L-type calcium channel subunit alpha-1S
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 6 | |||||
CYP2C9
Cytochrome P450 2C9
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.52 | None, None:None:None | ||||