nintedanib
A member of the class of oxindoles that is a kinase inhibitor used (in the form of its ethylsulfonate salt) for the treatment of idiopathic pulmonary fibrosis and cancer.
Ligand Summary
UNII: G6HRD2P839
PubChem: 9809715
Guide to Pharmacology: 5936
ChEMBL: CHEMBL502835
ChEMBL: CHEMBL3039504
DrugCentral: 4903
LyCHI: 41D7PT4QXULZ
Target Activities
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10
1 – 10 of 45
FLT3
Receptor-type tyrosine-protein kinase FLT3
10 Activities
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1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.58 | J. Med. Chem., (2009) 52:14:4466 | ||||
IC50 | 7.58 | Cancer Res., (2008) 68:12:4774 | ||||
Kd | 7.77 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.35 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.42 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.42 | J. Med. Chem., (2013) 56:20:8032 | ||||
Kd | 8.59 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.15 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.15 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.38 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
KDR
Vascular endothelial growth factor receptor 2
6 Activities
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1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.68 | J. Med. Chem., (2015) 58:3:1053 | ||||
IC50 | 7.68 | Cancer Res., (2008) 68:12:4774 | ||||
IC50 | 8.3 | J. Med. Chem., (2009) 52:14:4466 | ||||
Kd | 8.54 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 7.67999983 | |||||
IC50 | 8.30103016 | INHIBITOR | ||||
KIT
Mast/stem cell growth factor receptor Kit
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.54 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.2 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.24 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.54 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.57 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
PDGFRA
Platelet-derived growth factor receptor alpha
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.75 | J. Med. Chem., (2009) 52:14:4466 | ||||
Kd | 7.8 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.4 | Eur. J. Med. Chem., (2013) 65:None:477 | ||||
IC50 | 7.23000002 | |||||
IC50 | 7.74472761 | INHIBITOR | ||||
FLT4
Vascular endothelial growth factor receptor 3
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.89 | J. Med. Chem., (2015) 58:3:1053 | ||||
IC50 | 7.89 | Cancer Res., (2008) 68:12:4774 | ||||
IC50 | 8.3 | J. Med. Chem., (2009) 52:14:4466 | ||||
IC50 | 7.88999987 | |||||
IC50 | 8.30103016 | INHIBITOR | ||||
PDGFRB
Platelet-derived growth factor receptor beta
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.82 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.7 | Eur. J. Med. Chem., (2013) 65:None:477 | ||||
IC50 | 7.19000006 | |||||
Kd | 7.82 | INHIBITOR | ||||
LCK
Tyrosine-protein kinase Lck
3 Activities
CDK16
Cyclin-dependent kinase 16
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.68 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.68 | |||||
INSRR
Insulin receptor-related protein
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.68 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.68 | |||||
MAP3K19
Mitogen-activated protein kinase kinase kinase 19
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 8.28 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.28 | |||||