Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

KDR

Tclin

Vascular endothelial growth factor receptor 2

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.68		18559524

Kd	8.54	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.51	ACS Med Chem Lett, (2017) 8:11:1142	29152045

IC50	8.48	Bioorg Med Chem, (2017) 25:6:1778	28190652

IC50	8.33	Bioorg Med Chem, (2020) 28:11:115486	32305182

IC50	8.3	J. Med. Chem., (2009) 52:14:4466	19522465

IC50	8.07	Eur J Med Chem, (2017) 139:None:492	28826084

IC50	7.89	Eur J Med Chem, (2019) 179:None:916	31306818

IC50	7.68	Cancer Res., (2008) 68:12:4774	18559524

IC50	7.68	J. Med. Chem., (2015) 58:3:1053	25474320

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

11 Activities

Items per page:

1 – 10 of 11

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	9.38	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.15	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.15	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.59	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.42	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.42	J. Med. Chem., (2013) 56:20:8032	24044867

Kd	8.4	Science, (2017) 358:6367:None	29191878

Kd	8.35	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.77	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.58	J. Med. Chem., (2009) 52:14:4466	19522465

PDGFRB

Tclin

Platelet-derived growth factor receptor beta

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.19			18559524

IC50	8.74		ACS Med Chem Lett, (2017) 8:11:1142	29152045

IC50	8.7		Eur. J. Med. Chem., (2013) 65:None:477	23770449

IC50	8.46		Eur J Med Chem, (2017) 139:None:492	28826084

IC50	8.43		Bioorg Med Chem, (2017) 25:6:1778	28190652

IC50	8.42		Bioorg Med Chem, (2020) 28:11:115486	32305182

Kd	7.82		Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.82	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

FLT4

Tclin

Vascular endothelial growth factor receptor 3

7 Activities

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1 – 7 of 7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.89			18559524

IC50	8.52		Bioorg Med Chem, (2017) 25:6:1778	28190652

IC50	8.49		Eur J Med Chem, (2017) 139:None:492	28826084

IC50	8.3		J. Med. Chem., (2009) 52:14:4466	19522465

IC50	7.89		Cancer Res., (2008) 68:12:4774	18559524

IC50	7.89		J. Med. Chem., (2015) 58:3:1053	25474320

IC50	8.3	INHIBITOR	http://www.ncbi.nlm.nih.gov/pubmed/19522465

PDGFRA

Tclin

Platelet-derived growth factor receptor alpha

7 Activities

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1 – 7 of 7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.23			18559524

IC50	8.72		Bioorg Med Chem, (2017) 25:6:1778	28190652

IC50	8.64		Eur J Med Chem, (2017) 139:None:492	28826084

IC50	8.4		Eur. J. Med. Chem., (2013) 65:None:477	23770449

Kd	7.8		Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.75		J. Med. Chem., (2009) 52:14:4466	19522465

IC50	7.74	INHIBITOR	http://www.ncbi.nlm.nih.gov/pubmed/19522465

FLT1

Tclin

Vascular endothelial growth factor receptor 1

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.51			18559524

IC50	7.89		Eur J Med Chem, (2019) 179:None:916	31306818

IC50	7.64		Bioorg Med Chem, (2020) 28:11:115486	32305182

IC50	7.63		Bioorg Med Chem, (2017) 25:6:1778	28190652

IC50	6.98	INHIBITOR	http://www.ncbi.nlm.nih.gov/pubmed/19522465

KIT

Tclin

Mast/stem cell growth factor receptor Kit

5 Activities

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1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.57	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.54	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.24	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.2	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.54	Nat. Biotechnol., (2011) 29:11:1046	22037378

LCK

Tclin

Tyrosine-protein kinase Lck

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.21	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.8	J. Med. Chem., (2009) 52:14:4466	19522465

IC50	7.8	Cancer Res., (2008) 68:12:4774	18559524

MELK

Tchem

Maternal embryonic leucine zipper kinase

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.31	Nat. Biotechnol., (2011) 29:11:1046	22037378

Ki	8.25	Bioorg Med Chem, (2017) 25:9:2609	28351607

Kd	8.31	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

DDR1

Tchem

Epithelial discoidin domain-containing receptor 1

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.92	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.7	Science, (2017) 358:6367:None	29191878

Kd	7.92	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.52	Science, (2017) 358:6367:None	29191878

Kd	8.02	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.01	Nat. Biotechnol., (2011) 29:11:1046	22037378

FGFR1

Tclin

Fibroblast growth factor receptor 1

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.16			18559524

IC50	7.42	INHIBITOR	http://www.ncbi.nlm.nih.gov/pubmed/19522465

FGFR2

Tclin

Fibroblast growth factor receptor 2

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.43			18559524

Kd	6.46	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

FGFR3

Tclin

Fibroblast growth factor receptor 3

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.97			18559524

Kd	7.03	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

FGFR4

Tclin

Fibroblast growth factor receptor 4

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.21			18559524

Kd	5.74	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

ABL1

Tclin

Tyrosine-protein kinase ABL1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.55	Nat. Biotechnol., (2011) 29:11:1046	22037378

STK16

Tchem

Serine/threonine-protein kinase 16

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.75	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.74	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

CLK4

Tchem

Dual specificity protein kinase CLK4

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.75	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.74	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

CLK1

Tchem

Dual specificity protein kinase CLK1

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.06	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.06	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

PRKG1

Tchem

cGMP-dependent protein kinase 1

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.85	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.85	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

ABCB1

Tchem

Multidrug resistance protein 1

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	6.56	Eur J Med Chem, (2019) 164:None:193	30594677

EC50	6.56	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

BMP2K

Tchem

BMP-2-inducible protein kinase

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.66	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.66	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

STK4

Tchem

Serine/threonine-protein kinase 4

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.05	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.05	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

AXL

Tchem

Tyrosine-protein kinase receptor UFO

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.92	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.92	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

MAP2K5

Tchem

Dual specificity mitogen-activated protein kinase kinase 5

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.74	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.74	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

MERTK

Tchem

Tyrosine-protein kinase Mer

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.07	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.07	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

SRPK3

Tchem

SRSF protein kinase 3

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.92	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.92	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

MAP3K7

Tchem

Mitogen-activated protein kinase kinase kinase 7

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.39	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.39	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

STK11

Tchem

Serine/threonine-protein kinase STK11

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.75	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.74	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

PIP4K2B

Tchem

Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.77	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.77	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

NUAK2

Tchem

NUAK family SNF1-like kinase 2

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.68	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.68	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

MAP3K19

Tchem

Mitogen-activated protein kinase kinase kinase 19

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.28	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.28	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

GRK4

Tchem

G protein-coupled receptor kinase 4

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.77	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.77	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

MAP3K2

Tchem

Mitogen-activated protein kinase kinase kinase 2

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.03	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.03	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

RIOK1

Tchem

Serine/threonine-protein kinase RIO1

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.64	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.64	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

INSRR

Tchem

Insulin receptor-related protein

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.68	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.68	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

TTK

Tchem

Dual specificity protein kinase TTK

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.66	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.66	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

CDK16

Tchem

Cyclin-dependent kinase 16

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.68	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.68	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

PRPF4B

Tchem

Serine/threonine-protein kinase PRP4 homolog

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.08	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.08	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835

KCNH2

Tclin

Potassium voltage-gated channel subfamily H member 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.59		ACS Med Chem Lett, (2017) 8:11:1142	29152045

INSR

Tclin

Insulin receptor

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.62		Nat. Biotechnol., (2011) 29:11:1046	22037378

SRC

Tclin

Proto-oncogene tyrosine-protein kinase Src

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.8		Bioorg Med Chem, (2020) 28:11:115486	32305182

JAK3

Tclin

Tyrosine-protein kinase JAK3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)