nintedanib
Ligand Summary
UNII: G6HRD2P839
PubChem: 9809715
Guide to Pharmacology: 5936
ChEMBL: CHEMBL502835
ChEMBL: CHEMBL3039504
DrugCentral: 4903
LyCHI: 41D7PT4QXULZ
Target Activities
KDR
Vascular endothelial growth factor receptor 2
12 Activities
Items per page:
1 – 10 of 12
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.68 | |||||
Kd | 8.54 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.51 | ACS Med Chem Lett, (2017) 8:11:1142 | ||||
IC50 | 8.48 | Bioorg Med Chem, (2017) 25:6:1778 | ||||
IC50 | 8.33 | Bioorg Med Chem, (2020) 28:11:115486 | ||||
IC50 | 8.3 | J. Med. Chem., (2009) 52:14:4466 | ||||
IC50 | 8.07 | Eur J Med Chem, (2017) 139:None:492 | ||||
IC50 | 7.89 | Eur J Med Chem, (2019) 179:None:916 | ||||
IC50 | 7.68 | Cancer Res., (2008) 68:12:4774 | ||||
IC50 | 7.68 | J. Med. Chem., (2015) 58:3:1053 | ||||
FLT3
Receptor-type tyrosine-protein kinase FLT3
11 Activities
Items per page:
1 – 10 of 11
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 9.38 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.15 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.15 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.59 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.42 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.42 | J. Med. Chem., (2013) 56:20:8032 | ||||
Kd | 8.4 | Science, (2017) 358:6367:None | ||||
Kd | 8.35 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.77 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 7.58 | J. Med. Chem., (2009) 52:14:4466 | ||||
PDGFRB
Platelet-derived growth factor receptor beta
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.19 | |||||
IC50 | 8.74 | ACS Med Chem Lett, (2017) 8:11:1142 | ||||
IC50 | 8.7 | Eur. J. Med. Chem., (2013) 65:None:477 | ||||
IC50 | 8.46 | Eur J Med Chem, (2017) 139:None:492 | ||||
IC50 | 8.43 | Bioorg Med Chem, (2017) 25:6:1778 | ||||
IC50 | 8.42 | Bioorg Med Chem, (2020) 28:11:115486 | ||||
Kd | 7.82 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.82 | INHIBITOR | ||||
FLT4
Vascular endothelial growth factor receptor 3
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.89 | |||||
IC50 | 8.52 | Bioorg Med Chem, (2017) 25:6:1778 | ||||
IC50 | 8.49 | Eur J Med Chem, (2017) 139:None:492 | ||||
IC50 | 8.3 | J. Med. Chem., (2009) 52:14:4466 | ||||
IC50 | 7.89 | Cancer Res., (2008) 68:12:4774 | ||||
IC50 | 7.89 | J. Med. Chem., (2015) 58:3:1053 | ||||
IC50 | 8.3 | INHIBITOR | ||||
PDGFRA
Platelet-derived growth factor receptor alpha
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.23 | |||||
IC50 | 8.72 | Bioorg Med Chem, (2017) 25:6:1778 | ||||
IC50 | 8.64 | Eur J Med Chem, (2017) 139:None:492 | ||||
IC50 | 8.4 | Eur. J. Med. Chem., (2013) 65:None:477 | ||||
Kd | 7.8 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 7.75 | J. Med. Chem., (2009) 52:14:4466 | ||||
IC50 | 7.74 | INHIBITOR | ||||
FLT1
Vascular endothelial growth factor receptor 1
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.51 | |||||
IC50 | 7.89 | Eur J Med Chem, (2019) 179:None:916 | ||||
IC50 | 7.64 | Bioorg Med Chem, (2020) 28:11:115486 | ||||
IC50 | 7.63 | Bioorg Med Chem, (2017) 25:6:1778 | ||||
IC50 | 6.98 | INHIBITOR | ||||
KIT
Mast/stem cell growth factor receptor Kit
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.57 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.54 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.24 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.2 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.54 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
LCK
Tyrosine-protein kinase Lck
3 Activities
MELK
Maternal embryonic leucine zipper kinase
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.31 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Ki | 8.25 | Bioorg Med Chem, (2017) 25:9:2609 | ||||
Kd | 8.31 | |||||
DDR1
Epithelial discoidin domain-containing receptor 1
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.92 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.7 | Science, (2017) 358:6367:None | ||||
Kd | 7.92 | |||||
RET
Proto-oncogene tyrosine-protein kinase receptor Ret
3 Activities
FGFR1
Fibroblast growth factor receptor 1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.16 | |||||
IC50 | 7.42 | INHIBITOR | ||||
FGFR2
Fibroblast growth factor receptor 2
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.43 | |||||
Kd | 6.46 | INHIBITOR | ||||
FGFR3
Fibroblast growth factor receptor 3
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.97 | |||||
Kd | 7.03 | INHIBITOR | ||||
FGFR4
Fibroblast growth factor receptor 4
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.21 | |||||
Kd | 5.74 | INHIBITOR | ||||
ABL1
Tyrosine-protein kinase ABL1
2 Activities
STK16
Serine/threonine-protein kinase 16
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.75 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.74 | |||||
CLK4
Dual specificity protein kinase CLK4
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.75 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.74 | |||||
CLK1
Dual specificity protein kinase CLK1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.06 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.06 | |||||
PRKG1
cGMP-dependent protein kinase 1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.85 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.85 | |||||
ABCB1
Multidrug resistance protein 1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 6.56 | Eur J Med Chem, (2019) 164:None:193 | ||||
EC50 | 6.56 | |||||
BMP2K
BMP-2-inducible protein kinase
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.66 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.66 | |||||
STK4
Serine/threonine-protein kinase 4
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.05 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.05 | |||||
AXL
Tyrosine-protein kinase receptor UFO
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.92 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.92 | |||||
MAP2K5
Dual specificity mitogen-activated protein kinase kinase 5
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.74 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.74 | |||||
MERTK
Tyrosine-protein kinase Mer
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.07 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.07 | |||||
SRPK3
SRSF protein kinase 3
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.92 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.92 | |||||
MAP3K7
Mitogen-activated protein kinase kinase kinase 7
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.39 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.39 | |||||
STK11
Serine/threonine-protein kinase STK11
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.75 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.74 | |||||
PIP4K2B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.77 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.77 | |||||
NUAK2
NUAK family SNF1-like kinase 2
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.68 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.68 | |||||
MAP3K19
Mitogen-activated protein kinase kinase kinase 19
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.28 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.28 | |||||
GRK4
G protein-coupled receptor kinase 4
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.77 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.77 | |||||
MAP3K2
Mitogen-activated protein kinase kinase kinase 2
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.03 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.03 | |||||
RIOK1
Serine/threonine-protein kinase RIO1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.64 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.64 | |||||
INSRR
Insulin receptor-related protein
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.68 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.68 | |||||
TTK
Dual specificity protein kinase TTK
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.66 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.66 | |||||
CDK16
Cyclin-dependent kinase 16
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.68 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.68 | |||||
PRPF4B
Serine/threonine-protein kinase PRP4 homolog
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.08 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.08 | |||||
KCNH2
Potassium voltage-gated channel subfamily H member 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.59 | ACS Med Chem Lett, (2017) 8:11:1142 | ||||
INSR
Insulin receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.62 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
SRC
Proto-oncogene tyrosine-protein kinase Src
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.8 | Bioorg Med Chem, (2020) 28:11:115486 | ||||
JAK3
Tyrosine-protein kinase JAK3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) |
---|