nifedipine
A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Ligand Summary
UNII: I9ZF7L6G2L
PubChem: 4485
Guide to Pharmacology: 2514
ChEMBL: CHEMBL193
DrugCentral: 1922
LyCHI: QHYV239QLPDL
Target Activities
CACNA1C
Voltage-dependent L-type calcium channel subunit alpha-1C
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 7.7 | |||||
Kd | 9.4 | J. Med. Chem., (1995) 38:1:119 | ||||
Ki | 9 | J. Med. Chem., (1987) 30:4:690 | ||||
IC50 | 7.66 | Journal of Applied Toxicology, (2012) 32:None:858 | ||||
IC50 | 7.3 | Journal of Applied Toxicology, (2012) 32:None:858 | ||||
IC50 | 7.26 | Journal of Applied Toxicology, (2012) 32:None:858 | ||||
Kd | 9.4 | BLOCKER | ||||
CACNA1D
Voltage-dependent L-type calcium channel subunit alpha-1D
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.7 | |||||
IC50 | 5.87 | J. Med. Chem., (2014) 57:10:4313 | ||||
IC50 | 7.7 | GATING INHIBITOR | ||||
CYP1A2
Cytochrome P450 1A2
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
AC50 | 7.4 | None, None:None:None | ||||
AC50 | 7.3 | None, None:None:None | ||||
IC50 | 6.52 | None, None:None:None | ||||
CACNA1F
Voltage-dependent L-type calcium channel subunit alpha-1F
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 6 | |||||
IC50 | 6 | GATING INHIBITOR | ||||
GLRB
Glycine receptor subunit beta
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.9 | |||||
IC50 | 4.9 | |||||
KCNA5
Potassium voltage-gated channel subfamily A member 5
2 Activities
CACNA1S
Voltage-dependent L-type calcium channel subunit alpha-1S
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 6.3 | |||||
GLRA1
Glycine receptor subunit alpha-1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.5 | |||||
GLRA3
Glycine receptor subunit alpha-3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 4.5 | |||||
KCNA1
Potassium voltage-gated channel subfamily A member 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 4 | |||||
KCNA2
Potassium voltage-gated channel subfamily A member 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 4.7 | |||||
KCNA7
Potassium voltage-gated channel subfamily A member 7
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
4.9 | ||||||
KCNC1
Potassium voltage-gated channel subfamily C member 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
3.9 | ||||||