naloxone
A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
Ligand Summary
Target Activities
OPRM1
Mu-type opioid receptor
27 Activities
Items per page:
1 – 10 of 27
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.7 | None, None:None:None | ||||
Ki | 8.09 | None, None:None:None | ||||
Ki | 8.37 | Bioorg. Med. Chem. Lett., (2011) 21:13:4001 | ||||
Ki | 8.43 | Bioorg. Med. Chem. Lett., (2003) 13:24:4459 | ||||
Ki | 8.43 | J. Med. Chem., (2006) 49:25:7278 | ||||
Ki | 8.43 | J. Med. Chem., (2006) 49:25:7290 | ||||
Ki | 8.43 | Bioorg. Med. Chem. Lett., (2008) 18:6:2006 | ||||
Ki | 8.44 | J. Med. Chem., (2003) 46:11:2104 | ||||
Ki | 8.64 | MedChemComm, (2016) 7:2:317 | ||||
Ki | 8.64 | Bioorg. Med. Chem. Lett., (2011) 21:13:4001 | ||||
OPRD1
Delta-type opioid receptor
18 Activities
Items per page:
1 – 10 of 18
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.12 | J. Med. Chem., (2007) 50:9:2254 | ||||
IC50 | 7.21 | J. Med. Chem., (1992) 35:24:4589 | ||||
IC50 | 7.21 | J. Med. Chem., (1992) 35:13:2374 | ||||
Ki | 7.29 | J. Med. Chem., (2010) 53:3:1392 | ||||
Ki | 7.37 | J. Nat. Prod., (1993) 56:4:441 | ||||
Ki | 7.39 | Bioorg. Med. Chem. Lett., (2000) 10:6:523 | ||||
Ki | 7.42 | Bioorg. Med. Chem., (2011) 19:9:2808 | ||||
Ki | 7.43 | J. Med. Chem., (2003) 46:11:2104 | ||||
Ki | 7.48 | Bioorg. Med. Chem. Lett., (2003) 13:24:4459 | ||||
Ki | 7.48 | J. Med. Chem., (2006) 49:25:7278 | ||||
OPRK1
Kappa-type opioid receptor
17 Activities
Items per page:
1 – 10 of 17
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.12 | None, None:None:None | ||||
Ki | 7.52 | None, None:None:None | ||||
Ki | 7.82 | MedChemComm, (2016) 7:2:317 | ||||
Ki | 7.83 | J. Med. Chem., (2010) 53:10:4212 | ||||
Ki | 7.97 | J. Med. Chem., (2003) 46:11:2104 | ||||
Ki | 8.04 | Bioorg. Med. Chem. Lett., (2003) 13:24:4459 | ||||
Ki | 8.04 | J. Med. Chem., (2006) 49:25:7278 | ||||
Ki | 8.04 | J. Med. Chem., (2006) 49:25:7290 | ||||
Ki | 8.04 | Bioorg. Med. Chem. Lett., (2008) 18:6:2006 | ||||
Ki | 8.35 | Bioorg. Med. Chem., (2009) 17:14:5080 | ||||
ADORA3
Adenosine receptor A3
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.8 | J. Med. Chem., (2005) 48:22:6887 | ||||
IC50 | 8.8 | |||||