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molidustat

Ligand Summary
Ligand Structure
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Description
Molidustat (BAY 85–3934) is a novel, orally bioavailable HIF-PH inhibitor that mimics hypoxia by stabilizing HIF-a subunits. Molidustat inhibits HIF-PH, allowing the accumulation of HIF, which then translocates to the nucleus where it activates the transcription of erythropoietin (EPO) and other hypoxia-inducible genes, thereby increasing endogenous EPO levels and formation of the red blood cell.
Synonyms & Links
Guide to Pharmacology: 8456
DrugCentral: 5486
LyCHI:  XQ6L4GR3W4QR


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Target Activities