Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

ABCC1

Tchem

Multidrug resistance-associated protein 1

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.82	Mol. Pharmacol., (2006) 69:1:1499	16434618

IC50	8.82	Mol. Pharmacol., (2006) 69:1:1499	16434618

IC50	8.72	Mol. Pharmacol., (2006) 69:1:1499	16434618

IC50	7.56	J Med Chem, (2019) 62:18:8578	31465686

SLC47A1

Tchem

Multidrug and toxin extrusion protein 1

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.72	J. Med. Chem., (2013) 56:3:781	23241029

IC50	6.4	J. Med. Chem., (2013) 56:3:781	23241029

IC50	6.28	J. Med. Chem., (2013) 56:3:781	23241029

IC50	6.72	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL58

SLC47A2

Tchem

Multidrug and toxin extrusion protein 2

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.28	J. Med. Chem., (2013) 56:3:781	23241029

IC50	6.08	J. Med. Chem., (2013) 56:3:781	23241029

IC50	6.28	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL58

TOP2A

Tclin

DNA topoisomerase 2-alpha

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	5.28			18258442

IC90	5.96	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL58

KCNH2

Tclin

Potassium voltage-gated channel subfamily H member 2

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	5.53	None, None:None:None

IC50	5.45	None, None:None:None

CHRM4

Tclin

Muscarinic acetylcholine receptor M4

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.05		None, None:None:None

ABCG2

Tchem

ATP-binding cassette sub-family G member 2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.04		J Med Chem, (2019) 62:18:8578	31465686

CHRM2

Tclin

Muscarinic acetylcholine receptor M2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.11		None, None:None:None

PAX8

Tchem

Paired box protein Pax-8

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
AC50	6.16		None, None:None:None