mitotane
A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Ligand Summary
UNII: 78E4J5IB5J
PubChem: 4211
ChEMBL: CHEMBL1670
DrugCentral: 1820
LyCHI: SQALPCX5Y21A
Target Activities
SLC6A2
Sodium-dependent noradrenaline transporter
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.09 | None, None:None:None | ||||
Ki | 6.09 | None, None:None:None | ||||
SLC6A3
Sodium-dependent dopamine transporter
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6 | None, None:None:None | ||||
Ki | 6.1 | None, None:None:None | ||||
CYP11B1
Cytochrome P450 11B1, mitochondrial
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
INHIBITOR | ||||||
CYP11A1
Cholesterol side-chain cleavage enzyme, mitochondrial
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
INHIBITOR | ||||||