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migalastat

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Migalastat is a pharmacological chaperone that is designed to selectively and reversibly bind with high affinity to the active sites of certain mutant forms of alpha-Gal A, the genotypes of which are referred to as amenable mutations. Migalastat binding stabilizes these mutant forms of alpha-Gal A in the endoplasmic reticulum and facilitates their proper trafficking to lysosomes where dissociation of migalastat restores alpha-Gal A activity, leading to the catabolism of GL-3 and related substrates.
Synonyms & Links
Guide to Pharmacology: 10200
DrugCentral: 5110
LyCHI:  Y1A2RHTFZYAL


Target Activities