Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

CYP3A4

Tclin

Cytochrome P450 3A4

5 Activities

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1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7	None, None:None:None

IC50	6.75	J. Med. Chem., (2003) 46:9:1716	12699389

AC50	6.3	None, None:None:None

IC50	6.07	Eur. J. Med. Chem., (2009) 44:7:2913	19128860

IC50	6.07	Bioorg Med Chem Lett, (2019) 29:16:2016	31257085

SLC6A4

Tclin

Sodium-dependent serotonin transporter

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	6.38	None, None:None:None

IC50	6.11	None, None:None:None

CYP51A1

Tchem

Lanosterol 14-alpha demethylase

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.7	Drug Metab. Dispos., (2007) 35:3:493	17194716

IC50	6.7	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL91

CYP2C9

Tchem

Cytochrome P450 2C9

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
IC50	6.7	None, None:None:None

AC50	6.5	None, None:None:None

CYP2J2

Tchem

Cytochrome P450 2J2

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.24	Drug Metab. Dispos., (2012) 40:5:943	22328583

IC50	6.19	Drug Metab. Dispos., (2012) 40:5:943	22328583

CYP2C19

Tchem

Cytochrome P450 2C19

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
IC50	7.8	None, None:None:None

AC50	7.6	None, None:None:None

CYP2D6

Tclin

Cytochrome P450 2D6

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
AC50	6	None, None:None:None

IC50	6	None, None:None:None

TBXAS1

Tchem

Thromboxane-A synthase

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.58		None, None:None:None

CYP19A1

Tclin

Aromatase

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.22		Bioorg. Med. Chem. Lett., (2010) 20:10:3050	20413308

CYP17A1

Tclin

Steroid 17-alpha-hydroxylase/17,20 lyase

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.61		J. Med. Chem., (2003) 46:12:2345	12773039