metyrapone
An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
Ligand Summary
UNII: ZS9KD92H6V
PubChem: 4174
Guide to Pharmacology: 5224
ChEMBL: CHEMBL934
DrugCentral: 1791
LyCHI: MCCG1ACQPY4M
Target Activities
CYP11B1
Cytochrome P450 11B1, mitochondrial
14 Activities
Items per page:
1 – 10 of 14
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.84 | |||||
IC50 | 7.84 | Bioorg. Med. Chem. Lett., (2011) 21:1:186 | ||||
IC50 | 7.84 | MedChemComm, (2012) 3:6:663 | ||||
IC50 | 7.82 | ACS Med. Chem. Lett., (2011) 2:1:2 | ||||
IC50 | 7.82 | ACS Med. Chem. Lett., (2011) 2:8:559 | ||||
IC50 | 7.82 | J. Med. Chem., (2013) 56:15:6022 | ||||
IC50 | 7.82 | J. Med. Chem., (2014) 57:18:7811 | ||||
IC50 | 7.82 | Eur. J. Med. Chem., (2015) 89:None:106 | ||||
IC50 | 7.82 | Eur. J. Med. Chem., (2015) 96:None:139 | ||||
IC50 | 7.82 | None, (2016) None:None:None | ||||
CYP11B2
Cytochrome P450 11B2, mitochondrial
12 Activities
Items per page:
1 – 10 of 12
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.3 | J. Med. Chem., (2014) 57:18:7811 | ||||
IC50 | 7.38 | J. Med. Chem., (2013) 56:15:6022 | ||||
IC50 | 7.14 | Bioorg. Med. Chem. Lett., (2011) 21:1:186 | ||||
IC50 | 7.14 | ACS Med. Chem. Lett., (2011) 2:1:2 | ||||
IC50 | 7.14 | ACS Med. Chem. Lett., (2011) 2:8:559 | ||||
IC50 | 7.14 | MedChemComm, (2012) 3:6:663 | ||||
IC50 | 7.14 | Eur. J. Med. Chem., (2015) 89:None:106 | ||||
IC50 | 7.14 | Eur. J. Med. Chem., (2015) 96:None:139 | ||||
IC50 | 7.14 | None, (2016) None:None:None | ||||
IC50 | 7.14 | J Med Chem, (2017) 60:12:5086 | ||||
CYP3A4
Cytochrome P450 3A4
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.1 | None, None:None:None | ||||