Pharos : Ligand Details - metyrapone

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An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.

Ligand Summary

Ligand Structure

chemical structure image

Synonyms & Links

UNII: ZS9KD92H6V

PubChem: 4174

Guide to Pharmacology: 5224

ChEMBL: CHEMBL934

DrugCentral: 1791

LyCHI: MCCG1ACQPY4M

Target Activities

CYP11B1

Tclin

Cytochrome P450 11B1, mitochondrial

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.34		J. Med. Chem., (2014) 57:12:5011	24422519

IC50	7.82		None, (2016) None:None:None

IC50	7.82		ACS Med. Chem. Lett., (2011) 2:8:559	24900349

IC50	7.82		Eur. J. Med. Chem., (2015) 89:None:106	25462231

IC50	7.82		Eur. J. Med. Chem., (2015) 96:None:139	25874338

IC50	7.82		J. Med. Chem., (2013) 56:15:6022	23869452

IC50	7.82		ACS Med. Chem. Lett., (2011) 2:1:2	24900247

IC50	7.82		J. Med. Chem., (2014) 57:18:7811	25176013

IC50	7.84		MedChemComm, (2012) 3:6:663

IC50	7.84		Bioorg. Med. Chem. Lett., (2011) 21:1:186	21129965

CYP11B2

Tchem

Cytochrome P450 11B2, mitochondrial

11 Activities

Items per page:

1 – 10 of 11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.68		J. Med. Chem., (2014) 57:12:5011	24422519

IC50	7.14		None, (2016) None:None:None

IC50	7.14		MedChemComm, (2012) 3:6:663

IC50	7.14		Bioorg. Med. Chem. Lett., (2011) 21:1:186	21129965

IC50	7.14		ACS Med. Chem. Lett., (2011) 2:8:559	24900349

IC50	7.14		Eur. J. Med. Chem., (2015) 89:None:106	25462231

IC50	7.14		Eur. J. Med. Chem., (2015) 96:None:139	25874338

IC50	7.14		ACS Med. Chem. Lett., (2011) 2:1:2	24900247

IC50	7.38		J. Med. Chem., (2013) 56:15:6022	23869452

IC50	8.3		J. Med. Chem., (2014) 57:18:7811	25176013

CYP3A4

Tclin

Cytochrome P450 3A4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.1		None, None:None:None