Pharos : Ligand Details - mefenamic acid

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A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.

Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

UNII: 367589PJ2C

PubChem: 4044

Guide to Pharmacology: 2593

ChEMBL: CHEMBL686

DrugCentral: 1663

LyCHI: P8UZ3WH3XUYG

Target Activities

Explore Associated and Predicted Targets

PTGS1

Tclin

Prostaglandin G/H synthase 1

3 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	4.6			23454516

IC50	6.94		None, None:None:None

IC50	4.78	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL686

PTGS2

Tclin

Prostaglandin G/H synthase 2

3 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	5.54			23454516

IC50	6.22		None, None:None:None

IC50	6.83	INHIBITOR	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL686

AKR1C3

Tchem

Aldo-keto reductase family 1 member C3

3 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.52		J. Med. Chem., (2012) 55:17:7417	22881866

IC50	6.25		Eur. J. Med. Chem., (2013) 62:None:738	23454516

Ki	6.52		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL686

NAPRT

Tchem

Nicotinate phosphoribosyltransferase

3 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	10.3		None, None:None:None

Ki	10.3

Ki	10.3		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL686

MPO

Tchem

Myeloperoxidase

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.01		J Med Chem, (2017) 60:15:6563	28671460

IC50	6.01		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL686

AKR1C2

Tchem

Aldo-keto reductase family 1 member C2

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.66		J. Med. Chem., (2012) 55:17:7417	22881866

Ki	6.66		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL686

AKR1C1

Tchem

Aldo-keto reductase family 1 member C1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.09		J. Med. Chem., (2012) 55:17:7417	22881866

Ki	6.09		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL686