mefenamic acid
A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
Ligand Summary
UNII: 367589PJ2C
PubChem: 4044
Guide to Pharmacology: 2593
ChEMBL: CHEMBL686
DrugCentral: 1663
LyCHI: P8UZ3WH3XUYG
Target Activities
PTGS1
Prostaglandin G/H synthase 1
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 4.6 | |||||
IC50 | 6.94 | None, None:None:None | ||||
IC50 | 4.78 | INHIBITOR | ||||
PTGS2
Prostaglandin G/H synthase 2
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.54 | |||||
IC50 | 6.22 | None, None:None:None | ||||
IC50 | 6.83 | INHIBITOR | ||||
AKR1C3
Aldo-keto reductase family 1 member C3
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.52 | J. Med. Chem., (2012) 55:17:7417 | ||||
IC50 | 6.25 | Eur. J. Med. Chem., (2013) 62:None:738 | ||||
Ki | 6.52 | |||||
NAPRT
Nicotinate phosphoribosyltransferase
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 10.3 | None, None:None:None | ||||
Ki | 10.3 | |||||
Ki | 10.3 | |||||
MPO
Myeloperoxidase
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.01 | J Med Chem, (2017) 60:15:6563 | ||||
IC50 | 6.01 | |||||
AKR1C2
Aldo-keto reductase family 1 member C2
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.66 | J. Med. Chem., (2012) 55:17:7417 | ||||
Ki | 6.66 | |||||
AKR1C1
Aldo-keto reductase family 1 member C1
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.09 | J. Med. Chem., (2012) 55:17:7417 | ||||
Ki | 6.09 | |||||