maprotiline
A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
Ligand Summary
UNII: 2U1W68TROF
PubChem: 4011
Guide to Pharmacology: 2402
ChEMBL: CHEMBL21731
DrugCentral: 1634
LyCHI: GG92NA7HQ191
Target Activities
SLC6A2
Sodium-dependent noradrenaline transporter
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.92000008 | |||||
Ki | 7.92 | Bioorg. Med. Chem., (2009) 17:22:7802 | ||||
IC50 | 7.52 | None, None:None:None | ||||
Ki | 7.52 | None, None:None:None | ||||
Kd | 8.27 | INHIBITOR | ||||
HRH1
Histamine H1 receptor
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.99 | None, None:None:None | ||||
Ki | 8.78 | Bioorg. Med. Chem. Lett., (2009) 19:2:538 | ||||
IC50 | 8.06 | None, None:None:None | ||||
TRPM3
Transient receptor potential cation channel subfamily M member 3
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 5.80000019 | |||||
IC50 | 5.8 | BLOCKER | ||||
HTR2A
5-hydroxytryptamine receptor 2A
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.75 | None, None:None:None | ||||
IC50 | 7.19 | None, None:None:None | ||||
HTR2C
5-hydroxytryptamine receptor 2C
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.39 | None, None:None:None | ||||
IC50 | 7.11 | None, None:None:None | ||||
KCNJ6
G protein-activated inward rectifier potassium channel 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
4 | ||||||
KCNJ5
G protein-activated inward rectifier potassium channel 4
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
3.5 | ||||||
CHRM3
Muscarinic acetylcholine receptor M3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7 | None, None:None:None | ||||
CHRM4
Muscarinic acetylcholine receptor M4
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.24 | None, None:None:None | ||||